PMID: 3772047Nov 1, 1986Paper

Interdigestive plasma motilin concentrations in aged adults

Journal of Gerontology
G BonoraG Labò

Abstract

The interdigestive plasma motilin concentrations were evaluated in 13 over-65 healthy adults with no evidence of significant disease and in 19 younger individuals. Plasma motilin levels were determined every 15 min during a 3-hr fasting period, using a radioimmunological method. The individual median values of plasma motilin concentrations during the entire study period were significantly higher in aged than younger adults. The individual median coefficients of variation of motilin concentrations and the percentage increases of plasma motilin above baseline at each peak were significantly lower in the aged than in the young group. The results of this study indicate that during the interdigestive period aged individuals have markedly elevated circulating motilin levels, with less pronounced fluctuations than younger persons. This particular hormone pattern could be involved in motor disturbances of the stomach in elderly adults.

Citations

Sep 1, 1986·Digestive Diseases and Sciences·G VantrappenR Jian
Nov 1, 1996·Digestive Diseases and Sciences·T TomomasaP E Hyman
Dec 1, 1994·Digestive Diseases and Sciences·M HorowitzG Hebbard
Sep 24, 2015·Nature Reviews. Gastroenterology & Hepatology·Gareth J Sanger, John B Furness
Dec 15, 2015·American Journal of Physiology. Gastrointestinal and Liver Physiology·Eveline Deloose, Jan Tack
Jan 31, 2020·Expert Review of Gastroenterology & Hepatology·Kanageswari SingaramMaxim S Petrov
Dec 9, 2015·The Korean journal of gastroenterology = Taehan Sohwagi Hakhoe chi·Sung Eun Kim, Moo In Park
Jan 25, 2019·Nature Reviews. Endocrinology·Eveline DelooseJan Tack

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