Interdigital lesions and frequency of acute dermatolymphangioadenitis in lymphoedema in a filariasis-endemic area

The British Journal of Dermatology
T McPhersonR Hay

Abstract

Lymphatic filariasis (LF) is a mosquito-borne nematode infection that causes permanent lymphatic dysfunction in virtually all infected individuals and clinical disease in a subset of these. One major sequel of infection is lymphoedema of the limbs. Lymphoedema of the leg affects an estimated 15 million persons in LF-endemic areas worldwide. Acute dermatolymphangioadenitis (ADLA) in people with filarial lymphoedema causes acute morbidity and increasingly severe lymphoedema. Episodes of ADLA are believed to be caused by bacteria, and it has been shown that entry lesions in the skin play a causative role. Clinical observations suggest that interdigital skin lesions of the feet, often assumed to be fungal, may be of particular importance. To investigate the epidemiology and aetiology of interdigital lesions (IDL) of the feet in filarial lymphoedema. The frequency and mycological aetiology of IDL in 73 patients with filarial lymphoedema were compared with 74 individuals without lymphoedema in a region of Guyana highly endemic for Wuchereria bancrofti. More than 50% of patients with lymphoedema had one or more IDL (odds ratio 2.69; 95% confidence interval 1.31-5.66; P<0.005 compared with controls). The number of lesions was the stron...Continue Reading

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Nov 11, 2009·Annals of Tropical Medicine and Parasitology·C D MackenzieM N Malecela
Jul 19, 2016·Acta Tropica·Maria José NettoZulma Medeiros
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Jan 23, 2021·BMC Public Health·Samuel Opoku AsieduJohn Boulard Forkuor
Feb 27, 2020·Dermatology : International Journal for Clinical and Investigative Dermatology·David J ChandlerLucinda C Fuller

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