Abstract
Interdigitating dendritic cell sarcoma is an extremely rare neoplasm that mainly occurs in the lymph nodes. We report a case of interdigitating dendritic cell sarcoma arising from the spleen, a previously unreported site for interdigitating dendritic cell sarcoma. An 87-year-old woman, visiting Ashigara Hospital with complaints of palpitation and dyspnea, was found to have pancytopenia and low proteinemia. Abdominal ultrasonography and CT scanning demonstrated severe splenomegaly with heterogeneous enhancement. She received a splenectomy under the clinical diagnosis of a splenic tumor. Grossly, the spleen was markedly enlarged, with confluent massive nodules. Microscopically, the normal architecture was effaced with diffuse proliferation of large pleomorphic cells arrayed in a somewhat sheet-like pattern. Erythrophagocytosis was commonly observed. Immunohistochemical studies showed that the tumor cells were positive for S-100 protein, fascin, vimentin, and CD68, but uniformly negative for CD45, B- and T-cell markers, CD1a, CD30, complement receptors, CD34, Factor VIII, HMB-45, and lysozyme. Ultrastructurally, the tumor cells possessed complex interdigitating cytoplasmic dendritic processes. Birbeck granules were absent. Based o...Continue Reading
References
Jan 1, 1992·American Journal of Clinical Pathology·M YamakawaT Sato
Nov 1, 1991·Ultrastructural Pathology·S P HammarF L Remington
Jan 1, 1990·The Journal of Pathology·E RalfkiaerD Y Mason
May 1, 1990·The American Journal of Surgical Pathology·L M WeissR A Warnke
Feb 1, 1990·The Journal of Investigative Dermatology·M B TeunissenJ D Bos
Sep 1, 1989·American Journal of Clinical Pathology·L P RucoC D Baroni
Jun 1, 1986·American Journal of Clinical Pathology·W C Chan, G Zaatari
May 1, 1986·Histopathology·J J van den OordV J Desmet
Apr 15, 1988·Cancer·M S RabkinB Nathwani
May 1, 1988·The American Journal of Surgical Pathology·C FranchinoD M Knowles
Apr 1, 1987·The American Journal of Dermatopathology·P K HuiK Lennert
Feb 1, 1988·Cancer·S NakamuraJ Asai
Jun 1, 1985·The Journal of Pathology·J R SalisburyP G Isaacson
Jan 1, 1981·Virchows Archiv. A, Pathological Anatomy and Histology·C A FeltkampJ Koudstaal
Aug 1, 1993·Human Pathology·C HageP G Isaacson
May 1, 1994·Pathology International·S NakamuraT Suchi
Sep 1, 1993·American Journal of Clinical Pathology·M MiettinenJ Lasota
Dec 1, 1995·American Journal of Clinical Pathology·M A VasefR K Brynes
Sep 1, 1997·Diagnostic Cytopathology·B BannerB A Woda
Jan 1, 1997·Stem Cells·K Shortman, C Caux
Aug 28, 1998·Leukemia & Lymphoma·H KimuraY Maruyama
Sep 16, 1998·The American Journal of Surgical Pathology·J W AndrikoE S Jaffe
Oct 10, 1998·American Journal of Hematology·R FonsecaA Tefferi
Feb 10, 1999·Pathology International·S M LiuJ M Liu
Sep 9, 1999·The American Journal of Surgical Pathology·I S LukW F Ng
Apr 11, 2001·American Journal of Clinical Pathology·E M GaertnerJ A Andriko
Citations
Apr 5, 2005·Virchows Archiv : an International Journal of Pathology·Omer UluoğluNahide Gökçora
Nov 19, 2008·Cell and Tissue Research·Roland MollWerner W Franke
Apr 23, 2013·International Journal of Hematology·Yi-Zhi JiangSheng-Li Xue
Nov 6, 2010·Pathology Oncology Research : POR·Xi LiuXiaofeng Li
Jul 15, 2004·The American Journal of Surgical Pathology·Karen L GroggWilliam R Macon
Jan 22, 2009·The American Journal of Dermatopathology·John C LeeCarl J O'Hara
Dec 25, 2003·Journal of Clinical Pathology·N BarwellG Cook
Nov 23, 2011·Onkologie·Jianfeng ZhouYuzhou Wang
Feb 28, 2007·Diagnostic Pathology·Borislav A AlexievJohn C Papadimitriou
Dec 16, 2006·Leukemia & Lymphoma·Hassan NayerConstance A Griffin
Jun 13, 2013·Critical Reviews in Oncology/hematology·Caner SayginNukhet Tuzuner
Jun 25, 2015·Journal of Clinical and Experimental Hematopathology : JCEH·Chieko KyogokuShigeru Chiba
Feb 28, 2004·Histopathology·K PillayC C Sinclair-Smith
Jun 17, 2006·Journal of Cutaneous Pathology·John L FraterM Yadira Hurley
Jun 6, 2015·Cancer Biology & Therapy·Elisabetta Di LisoLaura Bonanno
Nov 16, 2005·Urology·G RuparC Langner
Aug 26, 2015·Der Pathologe·Alexandar Tzankov, Stephan Dirnhofer
Apr 22, 2015·Head and Neck Pathology·Valentina LupatoPaolo Boscolo-Rizzo
Feb 19, 2009·International Journal of Surgical Pathology·Zhi-yi ZhouMin-hong Pan
Jan 9, 2015·Rare Tumors·Stephen A RosenbergJames S Goydos
Feb 23, 2012·Rare Tumors·Ahmad MahamidAbdel-Rauf Zeina
Dec 9, 2010·Rare Tumors·Neal E DunlapPaul W Read
Feb 3, 2011·Journal of Korean Medical Science·Hye-Suk HanSeung Taik Kim
Jul 12, 2012·The Korean Journal of Hematology·Suk-Young LeeIn Sun Kim
Jul 20, 2007·American Journal of Hematology·Sebastien KairouzImad A Tabbara
Apr 22, 2008·Journal of Cutaneous Pathology·April DengJohn P Petrali
Jun 10, 2005·Diagnostic Cytopathology·Gita JayaramJaganathan Vijaya Sangkar
Oct 5, 2010·Asia-Pacific Journal of Clinical Oncology·Sun Young KimChang-Suk Kang
Aug 4, 2015·Neurosurgery·Gregor HutterKarl F Kothbauer
Nov 20, 2019·Annals of Hematology·Amr MuhammedEsraa Elnakib
Jun 15, 2016·The American Journal of Surgical Pathology·Anne M StowmanMark R Wick
May 15, 2019·Medicine·Chengchen ZhaoTianlun Yang
Oct 6, 2020·Seminars in Diagnostic Pathology·Sonam PrakashWayne Tam
Oct 17, 2003·Human Pathology·Maritza MartelJuan Rosai
Jul 31, 2007·Critical Reviews in Oncology/hematology·Tommaso De PasFilippo de Braud
Jul 1, 2009·American Journal of Otolaryngology·Guy EfuneLarry L Myers
Apr 20, 2010·Pathology, Research and Practice·Sonoko IshiharaKen-ichi Iyama
Nov 14, 2021·The Journal of International Medical Research·Peng HaoTao Wu