Interdigitating dendritic cell sarcoma of the spleen: report of a case with a review of the literature

The American Journal of Surgical Pathology
Kae KawachiKazuaki Misugi

Abstract

Interdigitating dendritic cell sarcoma is an extremely rare neoplasm that mainly occurs in the lymph nodes. We report a case of interdigitating dendritic cell sarcoma arising from the spleen, a previously unreported site for interdigitating dendritic cell sarcoma. An 87-year-old woman, visiting Ashigara Hospital with complaints of palpitation and dyspnea, was found to have pancytopenia and low proteinemia. Abdominal ultrasonography and CT scanning demonstrated severe splenomegaly with heterogeneous enhancement. She received a splenectomy under the clinical diagnosis of a splenic tumor. Grossly, the spleen was markedly enlarged, with confluent massive nodules. Microscopically, the normal architecture was effaced with diffuse proliferation of large pleomorphic cells arrayed in a somewhat sheet-like pattern. Erythrophagocytosis was commonly observed. Immunohistochemical studies showed that the tumor cells were positive for S-100 protein, fascin, vimentin, and CD68, but uniformly negative for CD45, B- and T-cell markers, CD1a, CD30, complement receptors, CD34, Factor VIII, HMB-45, and lysozyme. Ultrastructurally, the tumor cells possessed complex interdigitating cytoplasmic dendritic processes. Birbeck granules were absent. Based o...Continue Reading

References

Jan 1, 1992·American Journal of Clinical Pathology·M YamakawaT Sato
Nov 1, 1991·Ultrastructural Pathology·S P HammarF L Remington
May 1, 1990·The American Journal of Surgical Pathology·L M WeissR A Warnke
Feb 1, 1990·The Journal of Investigative Dermatology·M B TeunissenJ D Bos
Jun 1, 1986·American Journal of Clinical Pathology·W C Chan, G Zaatari
Apr 1, 1987·The American Journal of Dermatopathology·P K HuiK Lennert
Jun 1, 1985·The Journal of Pathology·J R SalisburyP G Isaacson
Dec 1, 1995·American Journal of Clinical Pathology·M A VasefR K Brynes
Oct 10, 1998·American Journal of Hematology·R FonsecaA Tefferi
Sep 9, 1999·The American Journal of Surgical Pathology·I S LukW F Ng
Apr 11, 2001·American Journal of Clinical Pathology·E M GaertnerJ A Andriko

❮ Previous
Next ❯

Citations

Apr 5, 2005·Virchows Archiv : an International Journal of Pathology·Omer UluoğluNahide Gökçora
Feb 28, 2007·Diagnostic Pathology·Borislav A AlexievJohn C Papadimitriou
Dec 16, 2006·Leukemia & Lymphoma·Hassan NayerConstance A Griffin
Jun 13, 2013·Critical Reviews in Oncology/hematology·Caner SayginNukhet Tuzuner
Jun 25, 2015·Journal of Clinical and Experimental Hematopathology : JCEH·Chieko KyogokuShigeru Chiba
Jun 6, 2015·Cancer Biology & Therapy·Elisabetta Di LisoLaura Bonanno
Aug 26, 2015·Der Pathologe·Alexandar Tzankov, Stephan Dirnhofer
Apr 22, 2015·Head and Neck Pathology·Valentina LupatoPaolo Boscolo-Rizzo
Feb 3, 2011·Journal of Korean Medical Science·Hye-Suk HanSeung Taik Kim
Jul 20, 2007·American Journal of Hematology·Sebastien KairouzImad A Tabbara
Apr 22, 2008·Journal of Cutaneous Pathology·April DengJohn P Petrali
Jun 10, 2005·Diagnostic Cytopathology·Gita JayaramJaganathan Vijaya Sangkar
Oct 5, 2010·Asia-Pacific Journal of Clinical Oncology·Sun Young KimChang-Suk Kang
Aug 4, 2015·Neurosurgery·Gregor HutterKarl F Kothbauer
Jun 15, 2016·The American Journal of Surgical Pathology·Anne M StowmanMark R Wick
Oct 6, 2020·Seminars in Diagnostic Pathology·Sonam PrakashWayne Tam
Jul 31, 2007·Critical Reviews in Oncology/hematology·Tommaso De PasFilippo de Braud
Jul 1, 2009·American Journal of Otolaryngology·Guy EfuneLarry L Myers
Nov 14, 2021·The Journal of International Medical Research·Peng HaoTao Wu

❮ Previous
Next ❯

Related Concepts

Related Feeds

Bacterial Cell Wall Structure

Bacterial cell walls are made of peptidoglycan (also called murein), which is made from polysaccharide chains cross-linked by unusual peptides containing D-amino acids. Here is the latest research on bacterial cell wall structures.

Bacterial Cell Wall Structure (ASM)

Bacterial cell walls are made of peptidoglycan (also called murein), which is made from polysaccharide chains cross-linked by unusual peptides containing D-amino acids. Here is the latest research on bacterial cell wall structures.