PMID: 20650165Dec 1, 1995Paper

Interdisciplinary approach to toxicity test development and validation

Toxicology in Vitro : an International Journal Published in Association with BIBRA
J M Frazier

Abstract

Toxicological processes are complex interactions of biological systems at various levels of organization. These interactions evolve in time in response to the perturbation resulting from the interaction of the toxicant, or its metabolite, with molecular targets in the organism. The successful development and validation of new in vitro toxicity tests for the toxicological evaluation of chemicals and commercial products require the concerted effort of an interdisciplinary research team. Such a team should consist of the following types of experts: (1) cell physiologist/cell culturist-someone who not only can grow cells of various origin but also can investigate the normal state of cells and how in vitro culture conditions affect this state; (2) molecular toxicologist-someone who understands the molecular mechanisms of toxicological responses (mechanisms of action) and can experimentally investigate their nature; (3) measurement technologist-an expert in instrumental technology and the application of these technologies to the measurement of cellular function and responses; (4) theoretical toxicologist/modeller-the integrator for the team who can pull the various aspects of the problem together into a unified picture connecting in ...Continue Reading

References

Sep 1, 1993·In Vitro Cellular & Developmental Biology. Animal·A M GoldbergJ A Bradlaw

❮ Previous
Next ❯

Citations

Dec 1, 1995·Toxicology in Vitro : an International Journal Published in Association with BIBRA·M Balls
Sep 20, 2002·Proceedings of the National Academy of Sciences of the United States of America·Joshua J TewksburyPatricia Townsend
Dec 20, 2014·Journal of Insect Science·Iwona SprawkaHubert Sytykiewicz
May 26, 1998·Environmental Health Perspectives·L H BrunerM Chamberlain
Dec 6, 2017·Toxicology in Vitro : an International Journal Published in Association with BIBRA·Shannon M BellNicole C Kleinstreuer

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Toxicology in Vitro : an International Journal Published in Association with BIBRA
M Roberfroid
Toxicology in Vitro : an International Journal Published in Association with BIBRA
H B Koëter
Toxicology in Vitro : an International Journal Published in Association with BIBRA
J P MorinC Monteil
Toxicology in Vitro : an International Journal Published in Association with BIBRA
J H FentemPhilip A Botham
Toxicology in Vitro : an International Journal Published in Association with BIBRA
C F Hendriksen
© 2021 Meta ULC. All rights reserved