Interdisciplinary diagnosis of and therapy for cholangiocarcinoma

Zeitschrift für Gastroenterologie
F T KolligsC Schäfer

Abstract

The diagnosis of and therapy for cholangiocarcinomas still remains an interdisciplinary challenge. For diagnostic and therapeutic purposes intra- and extrahepatic cholangiocarcinomas need to be distinguished. Multiple imaging tools such as sonography, multidetector computer tomography, magnetic resonance tomography as well as endoscopic ultrasound and endoscopic retrograde cholangiography for the diagnosis and localisation of these tumours are available. To date, surgical resection is the only curative treatment. At the time of diagnosis, most of the tumours are advanced. Therefore, only a small percentage of patients are suitable for curative surgery. Infiltration of the portal vein no longer constitutes a contraindication for surgery. Liver transplantation is not a reasonable option for intrahepatic cholangiocarcinomas but may be of advantage for perihilar Klatskin tumours. Severe cholangitis is the main cause of death of patients with obstructive cholangiocarcinomas. Drainage of the biliary tree system or surgery with construction of a biliary-digestive anastomosis is often necessary. If possible, a photodynamic therapy (PDT) should be performed in addition to biliary drainage. PDT has been shown to facilitate biliary draina...Continue Reading

Citations

Oct 7, 2011·International Journal of Cancer. Journal International Du Cancer·Thomas J VoglTatjana Gruber-Rouh
Sep 10, 2010·Der Chirurg; Zeitschrift für alle Gebiete der operativen Medizen·F RauchfussU Settmacher

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