PMID: 9432025Jan 31, 1998Paper

Interdonor variability of platelet response to thrombin receptor activation: influence of PlA2 polymorphism

British Journal of Haematology
D LasneF Rendu

Abstract

Considering that platelet response to thrombin receptor activation might be critical for the development of arterial thrombosis, we measured the dense granule release under stimulation by the thrombin receptor activating peptide (TRAP) in a series of 102 healthy volunteers. The threshold TRAP concentration which initiated a secretion ranged from 3 to 20 microM. A good concordance (79%, k=0.677) between two tests performed at a 1 month interval indicated that platelet response to thrombin receptor activation was characteristic of each individual donor. Since the threshold concentration required to initiate secretion corresponded to the threshold concentration which induced a biphasic aggregation, all volunteers were genotyped for the PlA2 polymorphism, the Pro33 variant of GPIIIa. Platelets from subjects with the PlA2 polymorphism required higher TRAP concentrations to aggregate than those from subjects with no PlA2 allele (P=0.0012). However, they also required a higher ADP concentration to aggregate. In order to exclude any influence of GPIIIa polymorphism on TRAP-induced secretion, we studied the variability of platelet response to TRAP among the 77 individuals with no PlA2 allele, and found the same interdonor variability wi...Continue Reading

Citations

Oct 12, 2000·Journal of the American College of Cardiology·J MikkelssonP J Karhunen
Jun 3, 1999·British Journal of Haematology·D J MeiklejohnM Greaves
Nov 13, 2001·Reviews in Clinical and Experimental Hematology·A P ReinerF R Rosendaal
Aug 9, 2012·Current Opinion in Hematology·Thomas J KunickiDiane J Nugent
Mar 23, 2000·The Journal of Clinical Investigation·T V Byzova, E F Plow
Nov 28, 2001·Pharmacogenomics·M J Quinn, E J Topol
Apr 9, 2005·American Journal of Pharmacogenomics : Genomics-related Research in Drug Development and Clinical Practice·Augusto Di CastelnuovoLicia Iacoviello
Dec 21, 2011·Steroids·Alessandra BertoniFabiola Sinigaglia
Jan 9, 2008·Blood Reviews·Isabelle I SallesHans Deckmyn
Jun 24, 2004·Vox Sanguinis·H DeckmynK Vanhoorelbeke
Apr 24, 2008·British Journal of Clinical Pharmacology·Timothy GoodmanPankaj Sharma
Apr 26, 2006·Journal of Thrombosis and Haemostasis : JTH·P FontanaP de Moerloose
Sep 13, 2005·La Revue de médecine interne·P Fontana, J-L Reny
Apr 9, 2008·European Journal of Vascular and Endovascular Surgery : the Official Journal of the European Society for Vascular Surgery·J McCaslinG Stansby
Jul 9, 2010·Blood·Thomas J Kunicki, Diane J Nugent
Dec 30, 2016·Platelets·Diane Nugent, Thomas Kunicki
Apr 9, 1999·Arteriosclerosis, Thrombosis, and Vascular Biology·W E WysokinskiW G Owen
Sep 17, 2002·Arteriosclerosis, Thrombosis, and Vascular Biology·Dougald M MonroeHarold R Roberts
Nov 21, 2009·Expert Opinion on Pharmacotherapy·Antonia M R BilleciValeria Caso
Aug 27, 2010·Blood Coagulation & Fibrinolysis : an International Journal in Haemostasis and Thrombosis·Faouzi AddadHabib Gamra

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