Interest and attitudes of patients, cancer physicians, medical students and cancer researchers towards a spectrum of genetic tests relevant to breast cancer patients

The Breast : Official Journal of the European Society of Mastology
Natalie NgoiAndrea Wong

Abstract

The perspectives of patients and healthcare professionals towards breast cancer genetic tests that are becoming increasingly available is unexplored in Asians. We surveyed the interest and attitudes of 200 breast cancer patients, 67 cancer physicians, 485 medical students and cancer researchers towards three genetic tests, BRCA1/2 mutation, CYP2D6 genotype and Oncotype DX testing, using hypothetical scenarios. Approximately 60% of patients expressed initial interest in each genetic test, although the majority reversed their decisions once test limitations were conveyed, with <15% maintaining interest in each test. Cancer physicians were most likely to recommend BRCA1/2 mutation testing (73%) and least likely to recommend CYP2D6 genotyping (12%), while patients were more likely to choose Oncotype DX testing (28%) over CYP2D6 (21%) and BRCA1/2 testing (15%). Cost concerns, low educational level and lack of prior awareness of genetic testing were the main barriers against breast cancer genetic testing among Asian patients.

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Citations

Jul 23, 2013·BMC Health Services Research·Wendy C BirminghamAnita Y Kinney
Dec 16, 2016·Genetics in Medicine : Official Journal of the American College of Medical Genetics·Barbara LernerMaren T Scheuner
Jun 25, 2017·Breast Cancer Research and Treatment·Ann H PartridgeBryan P Schneider
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Mar 1, 2017·Personalized Medicine·Lei-Shih ChenShixi Zhao
Jun 13, 2018·European Journal of Human Genetics : EJHG·Jean L PaulClara Gaff
Jan 5, 2021·Patient Education and Counseling·Megan Smith-UffenMegan Best

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