Interest of pharmacoepidemiology for pharmacodynamics and analysis of the mechanism of action of drugs

Thérapie
Maryse Lapeyre-Mestre, François Montastruc

Abstract

Pharmacology is often divided in separate branches, such as molecular and cellular pharmacology, pharmacokinetics, pharmacodynamics, experimental and/or preclinical pharmacology, clinical pharmacology (and therapeutics), pharmacogenetics, pharmacogenomics, pharmacovigilance, pharmacoepidemiology, pharmacoeconomics… This enumeration gives a global picture of different scientific areas, which are however dealing with the same question. Another mindset should be a global interactive and continuous approach, which could be designed as "human pharmacology". An original and attractive way to illustrate this continuous approach is to combine pharmacodynamics and pharmacovigilance and/or pharmacoepidemiologic data. Coupling disproportionality analyses in pharmacovigilance databases or computerized health databases, with pharmacological characteristics of drugs (receptor affinity, for example) allows investigating in humans, the mechanism of adverse drug reactions. Examples of such analyses investigating the risk of movement disorders, diabetes related to psychoactive drugs, or the risk of adverse cardiac outcomes with different drugs (classical drugs or protein kinase inhibitors) are given. The increasing number of research works inves...Continue Reading

References

Jan 8, 2005·European Heart Journal·M L De BruinH G M Leufkens
Jun 11, 2011·British Journal of Clinical Pharmacology·Jean-Louis MontastrucMaryse Lapeyre-Mestre
Aug 11, 2015·European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology·François MontastrucMaryse Lapeyre-Mestre
Oct 1, 2016·British Journal of Clinical Pharmacology·Thi Thu Ha NguyenFrançois Montastruc
Mar 5, 2017·Thérapie·Jacqueline Lehmann-CheAlexandre Evrard
May 19, 2018·Thérapie·Michaël RochoyUNKNOWN Réseau français des Centres Régionaux de Pharmacovigilance
Jun 29, 2018·British Journal of Clinical Pharmacology·Spyridon Siafis, Georgios Papazisis

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Citations

Dec 9, 2020·Schizophrenia Bulletin·Dainora CepaityteGeorgios Papazisis
Jan 12, 2021·Thérapie·Louise CartonRomain Guilhaumou
Feb 23, 2019·Thérapie·M Tournier, F Montastruc

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