Interest of Tumor-Specific CD4 T Helper 1 Cells for Therapeutic Anticancer Vaccine

Vaccines
Jeanne GalaineOlivier Adotévi

Abstract

Nowadays, immunotherapy represents one promising approach for cancer treatment. Recently, spectacular results of cancer immunotherapy clinical trials have confirmed the crucial role of immune system in cancer regression. Therapeutic cancer vaccine represents one widely used immunotherapy strategy to stimulate tumor specific T cell responses but clinical impact remains disappointing in targeting CD8 T cells. Although CD8 T cells have been initially considered to be the main protagonists, it is now clear that CD4 T cells also play a critical role in antitumor response. In this article, we discuss the role of tumor antigen-specific CD4 T cell responses and how we can target these cells to improve cancer vaccines.

References

Oct 31, 1998·Current Opinion in Immunology·D M Pardoll, S L Topalian
Mar 20, 2002·Cytokine & Growth Factor Reviews·Hiroaki IkedaRobert D Schreiber
Jun 1, 2002·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Mary L DisisKathy Schiffman
Jun 22, 2002·The Journal of Immunology : Official Journal of the American Association of Immunologists·Sander ZwavelingCornelis J M Melief
Oct 12, 2004·Nature Immunology·Christopher M SmithGabrielle T Belz
Feb 25, 2005·The Journal of Immunology : Official Journal of the American Association of Immunologists·Paul A AntonyNicholas P Restifo
Jul 13, 2005·Cancer Immunology, Immunotherapy : CII·K L Knutson, M L Disis
Oct 26, 2005·Proceedings of the National Academy of Sciences of the United States of America·Volker LennerzThomas Wölfel
May 16, 2006·Journal of Immunotherapy·Thomas F GajewskiHelena Harlin
Nov 24, 2007·Seminars in Immunology·Thomas KornEstelle Bettelli
Feb 23, 2008·The Journal of Immunology : Official Journal of the American Association of Immunologists·S B Justin WongLinda A Sherman
Mar 28, 2008·Immunological Reviews·Richard Kennedy, Esteban Celis
May 24, 2008·Current Opinion in Immunology·Hiroya Kobayashi, Esteban Celis
Jun 21, 2008·The New England Journal of Medicine·Naomi N HunderCassian Yee
Jun 21, 2008·The Journal of Immunology : Official Journal of the American Association of Immunologists·Xiao-Fei WangBernard Maillère
Aug 30, 2008·Blood·Jinfang Zhu, William E Paul
Sep 5, 2008·Expert Review of Vaccines·Gregory L Beatty, Robert H Vonderheide
Apr 25, 2009·Expert Opinion on Investigational Drugs·Jon Amund Kyte
Sep 2, 2009·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Mary L DisisLupe G Salazar
Nov 6, 2009·The New England Journal of Medicine·Gemma G KenterCornelis J M Melief
Feb 17, 2010·The Journal of Experimental Medicine·Ying XiePaul Andrew Antony
Dec 7, 2010·The Journal of Immunology : Official Journal of the American Association of Immunologists·Pavol KudelaHassane M Zarour
Jan 18, 2011·Current Opinion in Immunology·Sjoerd H van der Burg, Cornelis J M Melief
Feb 15, 2011·Annual Review of Immunology·Shane Crotty
Jun 22, 2011·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Craig L SlingluffWilliam W Grosh
Sep 16, 2011·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Paal Fr BrunsvigSteinar Aamdal
Nov 24, 2011·International Journal of Cancer. Journal International Du Cancer·Yoshihiro OhueEiichi Nakayama
Feb 9, 2012·Cancer Research·Rikke Sick AndersenSine Reker Hadrup
Mar 13, 2012·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Yann GodetOlivier Adotévi
Mar 16, 2012·Nature Reviews. Cancer·Wolf Herman FridmanJérôme Galon
Mar 23, 2012·Nature Reviews. Cancer·Drew M Pardoll

❮ Previous
Next ❯

Citations

Jul 22, 2017·Journal of Cellular Biochemistry·Jian Y ZouZhen G Chen
Sep 6, 2018·International Journal of Cancer. Journal International Du Cancer·Laurent BeziaudOlivier Adotévi
Jul 1, 2020·Immunological Reviews·Virgil SchijnsEd C Lavelle
Oct 1, 2016·Journal of Experimental & Clinical Cancer Research : CR·Mohanad Aldarouish, Cailian Wang
Mar 23, 2017·Cancer Immunology, Immunotherapy : CII·Yukio KobayashiYuji Heike
May 6, 2020·Acta Pharmacologica Sinica·Yang-Zhuo GuXiang-Rong Song
Apr 7, 2019·Journal of Experimental & Clinical Cancer Research : CR·Alessandra LopesVéronique Préat
Aug 29, 2017·Human Vaccines & Immunotherapeutics·Kaïdre Bendjama, Eric Quemeneur
Jul 7, 2018·Seminars in Immunopathology·T TranEric Tartour
Apr 25, 2020·Cancers·Irati Beltrán HernándezSabrina Oliveira
Jul 16, 2021·Frontiers in Immunology·Elodie RenaudeOlivier Adotévi
Nov 24, 2021·Chemical Record : an Official Publication of the Chemical Society of Japan ... [et Al.]·Natascha StergiouPol Besenius

❮ Previous
Next ❯

Methods Mentioned

BETA
single cell sequencing

Clinical Trials Mentioned

NCT00683670
NCT02287428
NCT01970358
NCT02129075
NCT02035956

Related Concepts

Related Feeds

Cancer Vaccines

Cancer vaccines are vaccines that either treat existing cancer or prevent development of a cancer.

Related Papers

Clinical Cancer Research : an Official Journal of the American Association for Cancer Research
Katherine Woods, Jonathan Cebon
Current Opinion in Immunology
D M Pardoll, S L Topalian
The Oncologist
Igor Espinoza-Delgado
© 2021 Meta ULC. All rights reserved