Interethnic differences in the prevalence of main cardiovascular pharmacogenetic biomarkers.

Pharmacogenomics
Karin Badavievich MirzaevDmitry Alekseevich Sychev

Abstract

Background: The aim of this study was to determine the prevalence of CYP2C9, VKORC1, CYP2C19, ABCB1, CYP2D6 and SLCO1B1 genes polymorphisms among residents of the Volga region (Chuvash and Mari) and northern Caucasus (Kabardins and Ossetians). Materials & methods: The study involved 845 apparently healthy volunteers of both sexes of the four different ethnic groups living in the Russian Federation: 238 from the Chuvash ethnic group, 206 Mari, 157 Kabardins and 244 Ossetians. Results: Significant differences were identified in allele frequency of CYP2C9, VKORC1, CYP2C19, ABCB1, CYP2D6 and SLCO1B1 genes polymorphisms between the Chuvash and Kabardins, Chuvash and Ossetians, Mari and Kabardians, Mari and Ossetians.

References

Jul 25, 2003·European Journal of Clinical Pharmacology·Elena A GaikovitchIvar Roots
Dec 31, 2004·American Journal of Human Genetics·Hua TangNeil J Risch
May 25, 2006·Bioinformatics·Xavier SoléVíctor Moreno
Nov 17, 2006·Pharmacogenetics and Genomics·Marja K PasanenMikko Niemi
Apr 10, 2007·Journal of the American College of Cardiology·Dominick J AngiolilloMarco A Costa
Jul 25, 2008·The New England Journal of Medicine·UNKNOWN SEARCH Collaborative GroupR Collins
Sep 12, 2008·Clinical Pharmacology and Therapeutics·M J BijlB H Ch Stricker
Oct 13, 2009·Clinical Pharmacokinetics·Shu-Feng Zhou
Nov 6, 2009·Clinical Pharmacology and Therapeutics·M Niemi
Mar 18, 2010·British Journal of Clinical Pharmacology·Alain Li-Wan-PoJames Lithgow
Mar 10, 2011·Basic & Clinical Pharmacology & Toxicology·Marjo VolotinenJukka Mäenpää
Nov 25, 2011·The New England Journal of Medicine·Daniel S BudnitzChesley L Richards
May 24, 2012·Clinical Pharmacology and Therapeutics·R A WilkeUNKNOWN Clinical Pharmacogenomics Implementation Consortium (CPIC)
Jun 11, 2014·British Journal of Clinical Pharmacology·Rashmi R Shah, Robert L Smith
Dec 19, 2014·Drug Metabolism and Disposition : the Biological Fate of Chemicals·Rashmi R Shah, Robert L Smith
Apr 17, 2015·Journal of Huazhong University of Science and Technology. Medical Sciences = Hua Zhong Ke Ji Da Xue Xue Bao. Yi Xue Ying De Wen Ban = Huazhong Keji Daxue Xuebao. Yixue Yingdewen Ban·Xuan NiuBo Hu
Apr 22, 2015·PLoS Genetics·Bayazit YunusbayevRichard Villems
May 4, 2015·European Heart Journal·Christoph VarenhorstUNKNOWN PLATO Investigators
Jun 19, 2015·European Heart Journal·Christian Hengstenberg, Adnan Kastrati
Feb 10, 2017·Pharmaceutical Research·Jasmine A LuzumJoseph P Kitzmiller
Jun 26, 2017·Archives of Cardiovascular Diseases·Loïc BelleUNKNOWN FAST-MI 2015 investigators
Oct 13, 2017·Genetic Testing and Molecular Biomarkers·Karin B MirzaevZhannet A Sozaeva
Oct 24, 2017·Current Genetic Medicine Reports·Sony Tuteja, Nita Limdi
Dec 29, 2017·Journal of Personalized Medicine·Ann K DalyJohn O Miners
Jan 11, 2018·Therapeutic Advances in Drug Safety·Rashmi R Shah, Andrea Gaedigk
May 4, 2018·Basic & Clinical Pharmacology & Toxicology·Miriam Saiz-RodríguezFrancisco Abad-Santos
Jul 17, 2019·Pharmacogenomics and Personalized Medicine·Frederick Zhang, Joseph Finkelstein
Aug 2, 2019·Pharmacogenomics·Karin B MirzaevDmitry A Sychev

❮ Previous
Next ❯

Citations

Mar 30, 2021·Drug Metabolism and Personalized Therapy·Anna Yu IkonnikovaTatiana V Nasedkina

❮ Previous
Next ❯

Methods Mentioned

BETA
pharmacotherapy
PCR
genotyping

Software Mentioned

PharmGKB
Statistical Package for Social Sciences ( SPSS )
GraphPad InStat

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Sovetskoe zdravookhranenie
N A BOGOIAVLENSKII
Veterinariia
I A El'sukov, N I Rozhkov
Clinical Advances in Hematology & Oncology : H&O
Victor R Gordeuk
© 2022 Meta ULC. All rights reserved