Interethnic diversity of the CD209 (rs4804803) gene promoter polymorphism in African but not American sickle cell disease

PeerJ
Jenelle A NobleBolaji N Thomas

Abstract

Elucidating the genomic diversity of CD209 gene promoter polymorphism could assist in clarifying disease pathophysiology as well as contribution to co-morbidities. CD209 gene promoter polymorphism has been shown to be associated with susceptibility to infection. We hypothesize that CD209 mutant variants occur at a higher frequency among Africans and in sickle cell disease. We analyzed the frequency of the CD209 gene (rs4804803) in healthy control and sickle cell disease (SCD) populations and determined association with disease. Genomic DNA was extracted from blood samples collected from 145 SCD and 231 control Africans (from Mali), 331 SCD and 379 control African Americans and 159 Caucasians. Comparative analysis among and between groups was carried out by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP). Per ethnic diversification, we found significant disparity in genotypic (23.4% versus 16.9% versus 3.2%) and allelic frequencies (48.7% versus 42.1% versus 19.8%) of the homozygote mutant variant of the CD209 (snp 309A/G) gene promoter between Africans, African Americans and Caucasians respectively. Comparative evaluation between disease and control groups reveal a significant difference in genotyp...Continue Reading

References

Jan 1, 1990·Child's Nervous System : ChNS : Official Journal of the International Society for Pediatric Neurosurgery·J CareyJ Nadell
Mar 1, 1985·Journal of Pediatric Orthopedics·A Mallouh, Y Talab
May 1, 1983·The American Journal of Medicine·S CharacheD S Bross
Mar 29, 1994·Proceedings of the National Academy of Sciences of the United States of America·L H Miller
Apr 1, 1997·Transfusion·L D PetzR M Herron
Sep 11, 1997·The New England Journal of Medicine·H F Bunn
Sep 11, 1999·Archives of Pediatrics & Adolescent Medicine·J E BeyerP M Woods
Sep 14, 2000·Annals of Hematology·A C MakisK L Bourantas
May 16, 2001·Science·C Zimmer
Feb 15, 2002·American Journal of Human Genetics·Heather E Collins-SchrammMichael F Seldin
Mar 14, 2002·American Journal of Human Genetics·Stephanie M FullertonAnna Di Rienzo
Jan 8, 2003·The Journal of Experimental Medicine·Ludovic TailleuxOlivier Neyrolles
Apr 12, 2003·The Journal of Experimental Medicine·Boonrat TassaneetrithepMary A Marovich
May 3, 2003·Trends in Molecular Medicine·Yvette van KooykTeunis B H Geijtenbeek
Sep 3, 2004·Current Biology : CB·Matthew V RockmanGregory A Wray
Oct 20, 2004·American Journal of Human Genetics·E E ThompsonA Di Rienzo
Nov 20, 2004·American Journal of Hematology·Anil PathareDavid Dennison
Apr 20, 2005·Nature Genetics·Anavaj SakuntabhaiCécile Julier
May 27, 2005·PLoS Medicine·Thomas N WilliamsKevin Marsh
Sep 13, 2005·Trends in Genetics : TIG·Anna Di Rienzo, Richard R Hudson
Oct 28, 2005·Genome Research·Bruce S WeirWilliam G Hill
Oct 28, 2005·Genome Research·Christopher S CarlsonDeborah A Nickerson
Dec 29, 2005·PLoS Medicine·Luis B BarreiroLluis Quintana-Murci
Jan 21, 2006·The Journal of Immunology : Official Journal of the American Association of Immunologists·Giovanna RappoccioloCharles R Rinaldo
Feb 24, 2006·PLoS Biology·Benjamin F VoightJonathan K Pritchard
Mar 15, 2006·Trends in Pharmacological Sciences·Martin H Steinberg
Jul 1, 2006·Trends in Genetics : TIG·Shameek Biswas, Joshua M Akey
Jan 9, 2007·Transfusion·Dimas Tadeu CovasAparecida Maria Fontes
May 8, 2007·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Natasha B HalasaMarie R Griffin
Feb 12, 2009·Hemoglobin·Nicola ConranFernando F Costa
May 26, 2009·Nature Genetics·Muminatou JallowUNKNOWN Malaria Genomic Epidemiology Network
Apr 2, 2010·American Journal of Preventive Medicine·Kathryn L Hassell

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Methods Mentioned

BETA
transgenic
PCR

Software Mentioned

It LS Image Analysis
PERL
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