Interface mechanics and histomorphometric analysis of hydroxyapatite-coated and porous glass-ceramic implants in canine bone

Journal of Biomedical Materials Research
L NimbK Gotfredsen

Abstract

A canine study was performed to make a histological and biomechanical evaluation of the interface between bone and two different bioceramic implants. A newly developed glass-ceramic formed by P2O5, CaO, SiO2, and Al2O3, giving a crystal phase composed of CaP2O6-AlPO4-SiP2O7, was compared to hydroxyapatite (HA) coated Ti-6Al-4V implants. A total of 24 implants were inserted into the femoral condyle of 15 adult female golden retriever dogs weighing 20-25 kg. There was a 12 week follow-up. Implants were examined by mechanical testing, histology, histomorphometry, microradiograpic methods, and EDAX analysis. The ultimate shear strength for the HA-coated implants was significantly higher than in the glass-ceramic group. When these values were related to the histomorphometric measurements, the difference could be explained by the tissue-to-implant contact. The glass-ceramic showed direct contact only with nonmineralized, osteoid bone. The HA-coated implants, however, were integrated into the bone. The study indicated that porous glass-ceramic containing AlPO4 causes local osteomalacia and might not be suitable for clinical purposes.

References

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Citations

Dec 30, 1999·Biomaterials·D M FerrisR F Valentini
Jun 5, 1998·Journal of Dentistry·R StrangD Woods
Mar 1, 1997·Comptes rendus de l'Académie des sciences. Série III, Sciences de la vie·G AtlanE Lopez
Jun 7, 2013·Interface Focus·Kefeng WangXingdong Zhang
Apr 13, 2006·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·Zhiqing XingRichard A Smith
Sep 5, 2013·The Journal of Oral Implantology·Sergio Alexandre GehrkePaulo Guilherme Coelho
May 3, 2016·Indian Journal of Dentistry·Supreet KaurRanjan Malhotra
Jun 5, 2015·Clinical Implant Dentistry and Related Research·Sergio Alexandre Gehrke, Ulisses Tavares da Silva Neto
Mar 27, 2007·Journal of Biomedical Materials Research. Part B, Applied Biomaterials·Zhiqing XingRichard A Smith

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