Interfaces between allergen structure and diagnosis: know your epitopes

Current Allergy and Asthma Reports
Anna PomésAlexander Wlodawer

Abstract

Allergy diagnosis is based on the patient's clinical history and can be strengthened by tests that confirm the origin of sensitization. In the past 25 years, these tests have evolved from the exclusive in vivo or in vitro use of allergen extracts, to complementary molecular-based diagnostics that rely on in vitro measurements of IgE reactivity to individual allergens. For this to occur, an increase in our understanding of the molecular structure of allergens, largely due to the development of technologies such as molecular cloning and expression of recombinant allergens, X-ray crystallography, or nuclear magnetic resonance (NMR), has been essential. New in vitro microarray or multiplex systems are now available to measure IgE against a selected panel of purified natural or recombinant allergens. The determination of the three-dimensional structure of allergens has facilitated detailed molecular studies, including the analysis of antigenic determinants for diagnostic purposes.

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Citations

Dec 9, 2017·Database : the Journal of Biological Databases and Curation·Kiran KadamUrmila Kulkarni-Kale
Mar 1, 2019·Current Allergy and Asthma Reports·Geoffrey A MuellerLars C Pedersen
Jul 29, 2020·Protein Engineering, Design & Selection : PEDS·Monica L Fernández-QuinteroKlaus R Liedl
Sep 29, 2020·Frontiers in Immunology·Anna PomésMaksymilian Chruszcz

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