Interfacial electrostatics of poly(vinylamine hydrochloride), poly(diallyldimethylammonium chloride), poly-l-lysine, and poly-l-arginine interacting with lipid bilayers

Physical Chemistry Chemical Physics : PCCP
Alicia C McGeachyFranz M Geiger

Abstract

Charge densities of cationic polymers adsorbed to lipid bilayers are estimated from second harmonic generation (SHG) spectroscopy and quartz crystal microbalance with dissipation monitoring (QCM-D) measurements. The systems surveyed included poly(vinylamine hydrochloride) (PVAm), poly(diallyldimethylammonium chloride) (PDADMAC), poly-l-lysine (PLL), and poly-l-arginine (PLR), as well as polyalcohol controls. Upon accounting for the number of positive charges associated with each polyelectrolyte, the binding constants and apparent free energies of adsorption as estimated from SHG data are comparable despite differences in molecular masses and molecular structure, with ΔGads values of -61 ± 2, -58 ± 2, -57 ± 1, -52 ± 2, -52 ± 1 kJ mol-1 for PDADMAC400, PDADMAC100, PVAm, PLL, and PLR, respectively. Moreover, we find charge densities for polymer adlayers of approximately 0.3 C m-2 for poly(diallyldimethylammonium chloride) while those of poly(vinylamine) hydrochloride, poly-l-lysine, and poly-l-arginine are approximately 0.2 C m-2. Time-dependent studies indicate that polycation adsorption to supported lipid bilayers is only partially reversible for most of the polymers explored. Poly(diallyldimethylammonium chloride) does not demo...Continue Reading

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Citations

May 22, 2018·Chemical Science·Alicia C McGeachyFranz M Geiger
Dec 8, 2020·Journal of Biotechnology·Elvira RozhinaSvetlana Batasheva
Apr 24, 2019·The Journal of Physical Chemistry. B·Naomi DalchandFranz M Geiger
Aug 23, 2019·Langmuir : the ACS Journal of Surfaces and Colloids·Maria MorgaMarta Kujda-Kruk
Jan 1, 2020·ACS Applied Materials & Interfaces·Naomi DalchandFranz M Geiger
Oct 16, 2020·Langmuir : the ACS Journal of Surfaces and Colloids·Wojciech KopecMariusz Kepczynski
Jul 2, 2019·The Journal of Physical Chemistry. B·Mavis D BoamahFranz M Geiger

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Methods Mentioned

BETA
biosensors
quartz crystal microbalance
QCM-D

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