Interfacial free energy and the hydrophobic effect
Interfacial free energies demonstrate clearly that the antipathy between hydrocarbon and water rests on the strong attraction of water for itself. However, the unfavorable free energy associated with this antipathy, per unit area of contact between bulk hydrocarbon and water, is about 3-fold larger than a similar figure derived from solubility data per unit area of contact between a single dissolved hydrocarbon molecule and water. The discrepancy illustrates the difficulty in applying macroscopic concepts such as "interfacial surface" at the molecular level and can be formally resolved, at least qualitatively, by the predicted effect of surface curvature on surface tension.
Use of solvent cavity area and number of packed solvent molecules around a solute in regard to hydrocarbon solubilities and hydrophobic interactions
Hydrophobic regions on protein surfaces. Derivation of the solvation energy from their area distribution in crystallographic protein structures
Protein folding and association: insights from the interfacial and thermodynamic properties of hydrocarbons
Interaction of alkyl ammonium derivatives with red cells: hemolysis and sodium pump inhibition studies
Comparison of an enzyme-linked immunosorbent assay (ELISA) to gas chromatography (GC)--measurement of polychlorinated biphenyls (PCBs) in selected US fish extracts
Mechanism of the hydrophobic effect in the biomolecular recognition of arylsulfonamides by carbonic anhydrase
Gas-liquid transfer data used to analyze hydrophobic hydration and find the nature of the Kauzmann-Tanford hydrophobic factor
Revisiting ligand-induced conformational changes in proteins: essence, advancements, implications and future challenges
Electrostatic contributions to protein-protein interactions: fast energetic filters for docking and their physical basis
A mechanistic analysis of the increase in the thermal stability of proteins in aqueous carboxylic acid salt solutions
Effect of mutation of an amino acid residue near the catalytic site on the activity of Bacillus stearothermophilus alpha-amylase
Conformational proofreading: the impact of conformational changes on the specificity of molecular recognition
Ligand-induced protein mobility in complexes of carbonic anhydrase II and benzenesulfonamides with oligoglycine chains
Prediction of the critical micelle concentration in a lattice model for amphiphiles using a single-chain mean-field theory
Molecular dynamics simulation of amphiphilic molecules in solution: micelle formation and dynamic coexistence
Unified model of association-induced lower critical solution temperature phase separation and its application to solutions of telechelic poly(ethylene oxide) and of telechelic poly(N-isopropylacrylamide) in water
Uncovering the physical origin of the difference between aliphatic chain and aromatic ring in the "hydrophobic" effects on partial molar volume
Hydration properties and potentials of mean force of nonpolar amino acid residues in water: a pertubation theoretic approach
Improved protein-ligand binding affinity prediction by using a curvature-dependent surface-area model
Fine-tuned broad binding capability of human lipocalin-type prostaglandin D synthase for various small lipophilic ligands
Thermodynamic studies and binding mechanisms of cell-penetrating peptides with lipids and glycosaminoglycans
Surface Gibbs energy interaction of phospholipid/cholesterol monolayers deposited on mica with probe liquids
Thermodynamic analysis of water molecules at the surface of proteins and applications to binding site prediction and characterization
Binding and clustering of glycosaminoglycans: a common property of mono- and multivalent cell-penetrating compounds
Solvent accessible surface area and excluded volume in proteins. Analytical equations for overlapping spheres and implications for the hydrophobic effect
Water around fullerene shape amphiphiles: A molecular dynamics simulation study of hydrophobic hydration
Comparison of the effects of surface tension and osmotic pressure on the interfacial hydration of a fluid phospholipid bilayer
Recent developments in the theoretical, simulational, and experimental studies of the role of water hydrogen bonding in hydrophobic phenomena
Omniphobic Polyvinylidene Fluoride (PVDF) Membrane for Desalination of Shale Gas Produced Water by Membrane Distillation
Unfolding and refolding of the native structure of bovine pancreatic trypsin inhibitor studied by computer simulations
How Nothing Boosts Affinity: Hydrophobic Ligand Binding to the Virtually Vacated S1 ' Pocket of Thermolysin
The nucleotide sequence of 5 S ribosomal RNA from a protozoan species Chilomonas paramecium belonging to the class Phytomastigophorea
Hydration dynamics of proteins in reverse micelles probed by 1 H-NOESY/1 H-ROESY NMR and 17 O-nuclear quadrupole resonance (NQR)
The Amyloid as a Ribbon-Like Micelle in Contrast to Spherical Micelles Represented by Globular Proteins
Role of Protein-Water Interface in the Stacking Interactions of Granum Thylakoid Membranes-As Revealed by the Effects of Hofmeister Salts
The hydrophobicity of bacteria - an important factor in their initial adhesion at the air-water interface
Ion-specific weak adsorption of salts and water/octanol transfer free energy of a model amphiphilic hexapeptide
Implicit modeling of nonpolar solvation for simulating protein folding and conformational transitions
The binding of benzoarylsulfonamide ligands to human carbonic anhydrase is insensitive to formal fluorination of the ligand
Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.
Synthetic Genetic Array Analysis
Synthetic genetic arrays allow the systematic examination of genetic interactions. Here is the latest research focusing on synthetic genetic arrays and their analyses.
Congenital hyperinsulinism is caused by genetic mutations resulting in excess insulin secretion from beta cells of the pancreas. Here is the latest research.
Neural Activity: Imaging
Imaging of neural activity in vivo has developed rapidly recently with the advancement of fluorescence microscopy, including new applications using miniaturized microscopes (miniscopes). This feed follows the progress in this growing field.
Chronic Fatigue Syndrome
Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.
Epigenetic memory refers to the heritable genetic changes that are not explained by the DNA sequence. Find the latest research on epigenetic memory here.
Cell Atlas of the Human Eye
Constructing a cell atlas of the human eye will require transcriptomic and histologic analysis over the lifespan. This understanding will aid in the study of development and disease. Find the latest research pertaining to the Cell Atlas of the Human Eye here.
Femoral Neoplasms are bone tumors that arise in the femur. Discover the latest research on femoral neoplasms here.
STING Receptor Agonists
Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.