Interfacial kinetics effects on transdermal drug delivery: a computer modeling

Skin Research and Technology : Official Journal of International Society for Bioengineering and the Skin (ISBS) [and] International Society for Digital Imaging of Skin (ISDIS) [and] International Society for Skin Imaging (ISSI)
Malcolm M Q XingHoward I Maibach

Abstract

Percutaneous permeation is a frequently used approach in drug delivery, but the detailed physics process in the patch--stratum corneum (SC)--viable epidermis system remains unclear: the influence of the interphases in the multilayered structure has been little studied. This paper applied the finite-element method to develop a contact algorithm with an interphase element to account for the interphase barrier on drug diffusion and chemical absorption during a transdermal drug delivery process. A more realistic multilayer structure, including the patch, SC and viable epidermis, are incorporated into the algorithm. Both interphases between the patch and SC, and between SC and viable epidermis are considered. Our study confirms that the interphase transfer coefficients have a direct connection with drug concentration and flux distribution along the diffusion paths. The simulation results suggested a potential for the optimal control of drug diffusion. The partition coefficients and other interphase barrier factors can be incorporated into the model. The algorithm can deal with complicated geometrical conditions, which is difficult using classical analytical approaches. Furthermore, calibrated against experiments, the model may predi...Continue Reading

References

Apr 1, 1974·The Journal of Investigative Dermatology·K A Holbrook, G F Odland
May 1, 1993·Journal of Pharmaceutical Sciences·K KubotaH I Maibach
Aug 1, 1998·Journal of Controlled Release : Official Journal of the Controlled Release Society·A L Bunge
May 23, 2001·Advanced Drug Delivery Reviews·Y N Kalia, R H Guy
Jun 29, 2001·Skin Research and Technology : Official Journal of International Society for Bioengineering and the Skin (ISBS) [and] International Society for Digital Imaging of Skin (ISDIS) [and] International Society for Skin Imaging (ISSI)·F. TimárA. Horváth
Oct 1, 1961·Journal of Pharmaceutical Sciences·T HIGUCHI
Oct 22, 2005·Annals of Biomedical Engineering·Jee E RimWilliam W van Osdol

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Citations

Jan 21, 2012·Advanced Drug Delivery Reviews·H Frederick Frasch, Ana M Barbero
Nov 13, 2012·Advanced Drug Delivery Reviews·Arne NaegelGabriel Wittum

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