PMID: 3748602Jul 1, 1986Paper

Interference between different serodemes of Trypanosoma congolense in the establishment of superinfections in goats following transmission by tsetse

Parasite Immunology
R H DwingerS K Moloo

Abstract

When domestic ruminants cyclically infected with Trypanosoma congolense are superinfected with a different serodeme of the same species, an interference phenomenon occurs which delays the development of the second cyclical infection. Experiments were carried out to investigate the influence of the time interval between the two infections on the degree of interference and to follow the course of the superinfection clinically, serologically and histologically. Goats infected with tsetse-transmitted T. congolense IL 1587 were either infected simultaneously or 7, 14, 18, 28 or 35 days later with a different serodeme, T. congolense IL 1180. Skin reactions due to superinfection were either absent or smaller in size and delayed in onset compared with control animals undergoing a primary infection with T. congolense IL 1180 which had been initiated by tsetse fly bites. All animals were treated with the trypanocidal drug Berenil 21 days after superinfection and 3 weeks later challenged with T. congolense IL 1180 using tsetse flies. The goats that had been infected simultaneously with the two serodemes were immune to the homologous challenge, but 11 (85%) of the animals that had been superinfected were not. The effect of interference on ...Continue Reading

References

Jan 1, 1977·Transactions of the Royal Society of Tropical Medicine and Hygiene·M MurrayW I McIntyre
Dec 1, 1985·Annals of Tropical Medicine and Parasitology·G W Akol, M Murray
Nov 1, 1973·The Journal of General Virology·R J Cooper, H S Bedson
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Dec 1, 1963·Experimental Parasitology·W H LUMSDENP J WALKER

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Citations

Feb 1, 1996·Tropical Animal Health and Production·R BoidA G Luckins
May 25, 2012·BMC Veterinary Research·John KatereggaAlain François Vincent Boulangé
Jan 1, 1992·Biological cybernetics·J T BuchananS Grillner

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