Abstract
Interactions between transcription factors are an important means of regulating gene transcription, leading to modifications in the pattern of gene expression and cell fate. In this study, we report that the progesterone receptor (PR) can strongly interfere with transactivation mediated by the arylhydrocarbon receptor (AhR) in T47D breast cancer cells. This interference was not only demonstrated by induction of a transfected dioxin-responsive reporter plasmid but also on the AhR-mediated up-regulation of the endogenous cytochrome P450-1A1 activity. The interference was not mutual, as 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD), the most potent activator of the AhR, did not inhibit progestin-induced promoter activity. When the isoforms of the human PR, hPR-A and hPR-B, were expressed separately in HepG-2 hepatocarcinoma cells, both negatively interfered with the AhR signaling, indicating that the effect is not restricted to T47D cells. In addition, results obtained from studies with both antiprogestins and mutant receptors indicate differences in the underlying molecular mechanisms of repression for both PR isoforms. The suppression by hPR-A does not require additional gene expression or a full transcriptional competent conformat...Continue Reading
References
May 22, 1992·Science·H ReyesO Hankinson
Apr 1, 1992·Proceedings of the National Academy of Sciences of the United States of America·G S TakimotoK B Horwitz
Jun 15, 1991·Biochemical Pharmacology·T ZacharewskiS Safe
Jul 26, 1991·Cell·H R SchölerP Gruss
Mar 25, 1991·Nucleic Acids Research·L Klein-HitpassG U Ryffel
Sep 1, 1990·Proceedings of the National Academy of Sciences of the United States of America·D C SpinkJ F Gierthy
May 5, 1989·Cell·M E MeyerP Chambon
May 12, 1988·Nature·L ToraP Chambon
Jan 1, 1988·Journal of Cellular Physiology·B van der BurgE J van Zoelen
Dec 1, 1983·Endocrinology·K B Horwitz, P S Alexander
Jan 1, 1995·Pharmacology & Therapeutics·S H Safe
Mar 1, 1995·Environmental Health Perspectives·L S Birnbaum
Aug 1, 1994·Molecular and Cellular Endocrinology·N HarperS Safe
Apr 1, 1995·Molecular and Cellular Biology·W L KrausB S Katzenellenbogen
Dec 1, 1994·Molecular and Cellular Biology·D X WenD P McDonnell
Apr 1, 1994·The Journal of Steroid Biochemistry and Molecular Biology·D P McDonnellM E Goldman
Nov 26, 1993·Science·A Gibbons
Dec 15, 1995·Cell·D J MangelsdorfR M Evans
Mar 15, 1996·The Journal of Biological Chemistry·E KalkhovenB van der Burg
May 3, 1996·The Journal of Biological Chemistry·I Kharat, F Saatcioglu
Jun 11, 1996·Proceedings of the National Academy of Sciences of the United States of America·A M BambergerH M Schulte
May 1, 1996·Toxicology and Applied Pharmacology·A M CummingsL Birnbaum
Jun 21, 1996·The Journal of Biological Chemistry·X ZhangM K Bagchi
Nov 30, 1995·Molecular and Cellular Endocrinology·M ChristouC R Jefcoate
Sep 1, 1996·Fundamental and Applied Toxicology : Official Journal of the Society of Toxicology·A J MurkA Brouwer
Apr 1, 1996·Fundamental and Applied Toxicology : Official Journal of the Society of Toxicology·P M GarrisonM S Denison
Jan 1, 1996·Annual Review of Cell and Developmental Biology·J V Schmidt, C A Bradfield
Feb 1, 1997·Human Reproduction·A MayaniM Almagor
May 20, 1997·Biochemistry·B E GillesbyT R Zacharewski
Jul 1, 1994·Trends in Endocrinology and Metabolism : TEM·J P Whitlock
Citations
Nov 28, 2000·International Journal of Cancer. Journal International Du Cancer·B L BrockdorffA E Lykkesfeldt
Apr 22, 2004·Chemosphere·David J BrownGeorge C Clark
Nov 25, 2000·Toxicology·C DelescluseR Rahmani
May 29, 2000·European Journal of Obstetrics, Gynecology, and Reproductive Biology·I A Brosens, J J Brosens
Jan 5, 2000·Molecular and Cellular Endocrinology·C M KlingeH I Swanson
May 24, 2000·The Journal of Steroid Biochemistry and Molecular Biology·M WormkeS Safe
Mar 4, 2006·The Journal of Biological Chemistry·Yong-Heng ChenMichael R Stallcup
Jun 3, 2000·Annual Review of Pharmacology and Toxicology·Y Z GuC A Bradfield
Apr 15, 2014·Environmental Science & Technology·Markus BrinkmannHenner Hollert
Mar 31, 2005·Reproduction : the Official Journal of the Society for the Study of Fertility·P PocarS Hombach-Klonisch
May 4, 2001·Environmental Health Perspectives·I A MeertsA Brouwer
May 20, 2008·Expert Opinion on Drug Metabolism & Toxicology·José M Navas, Helmut Segner
Jul 25, 2009·Drug Metabolism Reviews·Katalin MonostoryZdenek Dvorak
Sep 3, 2010·Journal of Neurochemistry·M FernándezL Calzà
Mar 26, 2004·Biochemical Pharmacology·Pinpin LinWai-Sze Lo
May 9, 2012·Toxicology and Applied Pharmacology·Raimo PohjanvirtaJere Lindén
Apr 30, 2014·Archives of Toxicology·Felicitas RatajGeorg Kretzschmar
Aug 11, 2007·Toxicological Sciences : an Official Journal of the Society of Toxicology·Edwin SonneveldBart van der Burg
Aug 31, 2002·Oncogene·Alexander KoliopanosHelmut Friess
Apr 7, 2007·Arteriosclerosis, Thrombosis, and Vascular Biology·Sahoko IchiharaToyoaki Murohara
Aug 12, 2006·Journal of Experimental Zoology. Part A, Comparative Experimental Biology·Mark E HahnJoy M Lapseritis
Dec 7, 2007·American Journal of Hematology·Olga A GraTatyana V Nasedkina
Sep 28, 1999·Endocrinology·C L ChaffinD M Duffy
May 13, 2006·Endocrinology·Sandra L PetersenEdward D Hudgens
Apr 17, 1999·The Journal of Biological Chemistry·W K ChanC A Bradfield
Jan 20, 2004·The Journal of Biological Chemistry·Song WangOliver Hankinson
Feb 11, 2021·International Journal of Molecular Sciences·Jinyun ChenWilliam K Chan
Mar 19, 1999·Biochemical and Biophysical Research Communications·N R JanaH Sone