PMID: 9178829May 16, 1997Paper

Interference of bcl-2 with intercellular control of carcinogenesis

International Journal of Cancer. Journal International Du Cancer
J M Jürgensmeier, G Bauer

Abstract

Induction of apoptosis in transformed fibroblasts by surrounding normal cells has been discussed as a potent early control step in carcinogenesis. According to this hypothesis, tumor progression should require resistance of transformed cells against this TGF-beta-triggered control mechanism. Here we show that Bcl-2, a protein involved in inhibition of apoptosis, can protect transformed cells from induction of apoptosis by surrounding cells. Rather than acting on the transformation process itself, Bcl-2 may thus represent an efficient modulator of carcinogenesis at an intercellular level.

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Citations

Oct 19, 2004·Neuropathology and Applied Neurobiology·U SchüllerJ Herms
Jun 8, 2002·Prostaglandins, Leukotrienes, and Essential Fatty Acids·G Bauer
Jul 1, 2004·Nonlinearity in Biology, Toxicology, Medicine·Bobby R ScottVernon E Walker

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