Interference of beta 2-microglobulin specific autoantibodies with EA-binding of human peripheral lymphocytes; inhibition of B-cell and enhancement of T-lymphocyte Fc-receptors

Immunology Letters
A FalusJ Gergely

Abstract

The effect of anti-beta 2 m-specific autoantibodies was investigated on the FcRs of human PBMCs. Anti-beta 2 m autoantibodies inhibited the FcRs of the lymphocyte subpopulation detectable by rosetting with EA(hu). On the contrary, when EA(ox) indicator system was used, in the majority of the cases an enhancement of EA rosette formation was detected. Using separated lymphocyte subpopulations we found that the binding of anti-beta 2 m autoantibodies increased the number of FcR+ non-B-cells and inhibited that of B-lymphocytes.

References

Aug 1, 1979·Proceedings of the National Academy of Sciences of the United States of America·D LancetJ L Strominger
Jan 1, 1978·Vox Sanguinis·V de Villiers, J G Wilson
Aug 1, 1960·Archives of Biochemistry and Biophysics·A NISONOFFD L WOERNLEY

❮ Previous
Next ❯

Related Concepts

Related Feeds

Antibody Specificity

Antibodies produced by B cells are highly specific for antigen as a result of random gene recombination and somatic hypermutation and affinity maturation. As the main effector of the humoral immune system, antibodies can neutralize foreign cells. Find the latest research on antibody specificity here.