Interference of intrinsic curvature of DNA by DNA-intercalating agents

Organic & Biomolecular Chemistry
Hong Kee TanTianhu Li

Abstract

It has been demonstrated in our studies that the intrinsic curvature of DNA can be easily interrupted by low concentrations of chloroquine and ethidium bromide. In addition, the changes of DNA curvature caused by varying the concentration of these two DNA intercalators can be readily verified through using an atomic force microscope.

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Citations

Sep 25, 2014·Scientific Reports·Renato BuzioUgo Valbusa

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