PMID: 2484595Jul 1, 1989Paper

Interference of manganese on neuroendocrinal system in exposed workers. Preliminary report

Biological Trace Element Research
L AlessioS Lombardi

Abstract

The neurotoxic effects of Manganese (Mn) are well known, and are usually caused by high occupational exposure over long periods of time. The effects caused by low doses of this metal have been poorly evaluated. For this reason, we decided to evaluate neuroendocrinal tests in a group of 14 male workers employed in a ferrous-manganese foundry (exposed to Mn air concentrations within the TLV-TWA) and in 14 male control subjects, by analyzing FSH, LH, prolactin, and cortisol. The urinary Mn; prolactin, and cortisol levels were significantly higher in the worker's group. The preliminary results of this research seem to show that for exposure below the TLV, Mn can somehow interfere with the neuroendocrine system. In order to confirm the existence of these effects and to verify their possible correlation with the dopaminergic control system, further studies are necessary.

References

Sep 1, 1986·Toxicology Letters·L LucchiM Trabucchi
Oct 1, 1985·Biology of Reproduction·R Z SokolR S Swerdloff
Aug 1, 1984·Scandinavian Journal of Work, Environment & Health·A MuttiI Franchini

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Citations

Aug 22, 2007·Journal of Toxicology and Environmental Health. Part B, Critical Reviews·Annette B SantamariaFionna S Mowat
Jan 16, 2010·Journal of Toxicology and Environmental Health. Part a·Annette B Santamaria, Sandra I Sulsky
Mar 4, 2005·Critical Reviews in Toxicology·Michael AschnerDavid C Dorman
Mar 14, 2009·Biomarkers : Biochemical Indicators of Exposure, Response, and Susceptibility to Chemicals·Dallas M CowanWei Zheng
Aug 19, 2007·Biomarkers : Biochemical Indicators of Exposure, Response, and Susceptibility to Chemicals·Dag G EllingsenYngvar Thomassen
May 31, 2012·Biomarkers : Biochemical Indicators of Exposure, Response, and Susceptibility to Chemicals·Simona CatalaniPietro Apostoli
Sep 29, 2004·Neurotoxicology and Teratology·L TakserJ Lafond
Sep 5, 2006·Neurotoxicology·Eun A KimDong Mug Kang
Nov 5, 2013·Neurotoxicology·Dinamene SantosMichael Aschner
Oct 16, 2010·Neurotoxicology·Wei ZhengDallas M Cowan
Aug 2, 2015·Current Environmental Health Reports·Stefanie L O'Neal, Wei Zheng
Feb 24, 2001·Journal of Endocrinological Investigation·A BaccarelliP A Bertazzi

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