Interference of Monovalent, Bivalent, and Trivalent Oral Poliovirus Vaccines on Monovalent Rotavirus Vaccine Immunogenicity in Rural Bangladesh

Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America
Devy M EmperadorK Zaman

Abstract

Trivalent oral poliovirus vaccine (OPV) is known to interfere with monovalent rotavirus vaccine (RV1) immunogenicity. The interference caused by bivalent and monovalent OPV formulations, which will be increasingly used globally in coming years, has not been examined. We conducted a post hoc analysis to assess the effect of coadministration of different OPV formulations on RV1 immunogenicity. Healthy infants in Matlab, Bangladesh, were randomized to receive 3 doses of monovalent OPV type 1 or bivalent OPV types 1 and 3 at either 6, 8, and 10 or 6, 10, and 14 weeks of age or trivalent OPV at 6, 10, and 14 weeks of age. All infants received 2 doses of RV1 at about 6 and 10 weeks of age. Concomitant administration was defined as RV1 and OPV given on the same day; staggered administration as RV1 and OPV given ≥1 day apart. Rotavirus seroconversion was defined as a 4-fold rise in immunoglobulin A titer from before the first RV1 dose to ≥3 weeks after the second RV1 dose. There were no significant differences in baseline RV1 immunogenicity among the 409 infants included in the final analysis. Infants who received RV1 and OPV concomitantly, regardless of OPV formulation, were less likely to seroconvert (47%; 95% confidence interval, 39...Continue Reading

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Citations

Nov 3, 2016·The Journal of Infectious Diseases·Vanessa C HarrisWillem M de Vos
Jun 3, 2017·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·James A Platts-MillsEric R Houpt
Feb 3, 2018·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Benjamin LeeBeth D Kirkpatrick
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Dec 9, 2017·Future Microbiology·Edward Pk ParkerNicholas C Grassly
Jun 8, 2018·PloS One·Shabihah ShahrudinMohammed Alsharifi
Nov 17, 2016·Clinical and Vaccine Immunology : CVI·Katayi MwilaSylvia Becker-Dreps
Feb 2, 2018·Paediatric Drugs·Eleanor BurnettJacqueline Tate
Mar 27, 2019·The Cochrane Database of Systematic Reviews·Karla Soares-WeiserNigel Cunliffe
Jun 3, 2016·The Pediatric Infectious Disease Journal·Sasirekha RamaniMiguel L O'Ryan
Jul 16, 2019·Current Opinion in Infectious Diseases·Rachel M BurkeUmesh D Parashar
Nov 7, 2019·The Cochrane Database of Systematic Reviews·Karla Soares-WeiserNigel Cunliffe
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Jun 13, 2021·The Pediatric Infectious Disease Journal·Eleanor BurnettJacqueline E Tate
Nov 18, 2021·The Cochrane Database of Systematic Reviews·Hanna BergmanKarla Soares-Weiser

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