Interference of secretory immunoglobulin A with sorption of oral bacteria to hydroxyapatite.

Infection and Immunity
M KilianJ Mestecky

Abstract

The potential of secretory immunoglobulin A (S-IgA) to interfere with the initial phase of dental plaque formation was studied by using an in vitro method which permits the quantitative determination of the sorption of radiolabeled oral bacterial cells to hydroxyapatite (HA) beads. The importance of specific S-IgA antibodies was evaluated by a comparison of the effect of pure preparations of colostral S-IgA, polymeric myeloma IgA, or preabsorbed S-IgA. Specific antibody molecules bound at the HA surface significantly enhanced the sorption of two Streptococcus sanguis strains. In contrast, HA-bound S-IgA antibodies inhibited the sorption of Streptococcus mitior and Streptococcus salivarius. The same was true for Streptococcus mutans cells, but only when they were propagated in the absence of sucrose. Suspended in saliva, cells of all streptococcal species adhered in significantly lower numbers to HA. Comparative experiments with bacteria suspended in solutions of various preparations of IgA or immunoglobulin-deficient salivas with S-IgA or myeloma IgA added indicated that the adherence inhibition seen with S. Sanguis, S. mitior, S. salivarius, and glucose-grown S. mutans was partly attributable to functions of S-IgA antibodies. ...Continue Reading

References

Apr 1, 1976·Journal of Dental Research·I D Mandel
Feb 1, 1977·Journal of Dental Research·W F Liljemark, S V Schauer
Jan 1, 1978·Archives of Oral Biology·D BratthallB Krasse
Dec 1, 1979·Infection and Immunity·W F LiljemarkJ C Ofstehage
Mar 1, 1978·The Journal of Clinical Investigation·J MesteckyJ L Babb
Sep 1, 1975·Journal of Oral Pathology·R L Holt, J Mestecky
Jan 1, 1976·Caries Research·I MagnussonK Pruitt
Jan 1, 1975·Annual Review of Microbiology·R J Gibbons, J V Houte
Jan 1, 1974·Advances in Experimental Medicine and Biology·R J GencoM A Taubman
Jun 1, 1974·Archives of Oral Biology·M A Taubman
Jul 1, 1968·Journal of Bacteriology·P BrandtzaegS T Gjeruldsen
Jan 1, 1973·Journal of Oral Pathology·F W KrausC H Cook
May 1, 1974·Infection and Immunity·D OrstavikL C Henshaw
Sep 1, 1965·Immunochemistry·G ManciniJ F Heremans
Sep 1, 1970·Archives of Oral Biology·J D HillmanR J Gibbons
Oct 1, 1971·Archives of Oral Biology·J Van HouteA J Pulkkinen
Jul 1, 1965·Proceedings of the Society for Experimental Biology and Medicine·R T EVANS, S E MERGENHAGEN

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Citations

Jan 1, 1982·Infection·J van Houte
Oct 1, 1988·Journal of Dental Research·K T MiyasakiL E Wolinsky
Jan 1, 1993·Critical Reviews in Oral Biology and Medicine : an Official Publication of the American Association of Oral Biologists·M W Stinson, M J Levine
May 1, 1991·Journal of Clinical Periodontology·D K AbbasP Gjermo
Jan 1, 1991·Journal of Biomaterials Science. Polymer Edition·I H Pratt-TerpstraH J Busscher
Jul 29, 2003·Psychosomatic Medicine·Jos A BoschArie V Nieuw Amerongen
Jan 1, 1994·Critical Reviews in Oral Biology and Medicine : an Official Publication of the American Association of Oral Biologists·F A Scannapieco
Apr 8, 1998·Microbiology and Molecular Biology Reviews : MMBR·H Marcotte, M C Lavoie
Jan 1, 1982·Infection and Immunity·W E NesbittR R Arnold
Jun 1, 1984·Infection and Immunity·F M Eggert, B W Gurner
Jan 1, 1986·Infection and Immunity·J TenovuoP Tuohimaa
May 1, 1995·Infection and Immunity·S F Lee

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