Interference With Quorum-Sensing Signal Biosynthesis as a Promising Therapeutic Strategy Against Multidrug-Resistant Pathogens

Frontiers in Cellular and Infection Microbiology
Osmel Fleitas MartínezOctavio Luiz Franco

Abstract

Faced with the global health threat of increasing resistance to antibiotics, researchers are exploring interventions that target bacterial virulence factors. Quorum sensing is a particularly attractive target because several bacterial virulence factors are controlled by this mechanism. Furthermore, attacking the quorum-sensing signaling network is less likely to select for resistant strains than using conventional antibiotics. Strategies that focus on the inhibition of quorum-sensing signal production are especially attractive because the enzymes involved are expressed in bacterial cells but are not present in their mammalian counterparts. We review here various approaches that are being taken to interfere with quorum-sensing signal production via the inhibition of autoinducer-2 synthesis, PQS synthesis, peptide autoinducer synthesis, and N-acyl-homoserine lactone synthesis. We expect these approaches will lead to the discovery of new quorum-sensing inhibitors that can help to stem the tide of antibiotic resistance.

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Jul 11, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Shekh SabirNaresh Kumar
Jul 1, 2020·BioMed Research International·Min YangJie Yu
Nov 19, 2019·Frontiers in Microbiology·Paweł Krzyżek
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Nov 9, 2019·Ultrasound in Medicine & Biology·Kirby R LattweinKlazina Kooiman
Jan 30, 2021·Environmental Microbiology·Saima Khalid, Nancy P Keller
Nov 17, 2020·Frontiers in Cellular and Infection Microbiology·Jiali TangWeihua Chu
Oct 30, 2020·Infection and Drug Resistance·Shaymaa H Abdel-RhmanEman S Abdelmegeed
Dec 31, 2020·ACS Omega·Mohd Farhan KhanIqbal Ahmad

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Methods Mentioned

BETA
environmental stress
antisense oligonucleotides
antisense oligonucleotide

Software Mentioned

MTAP
Pymol
MTAN

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