Sep 1, 1987

Interference with the distribution and release of arachidonic acid in human keratinocytes by bradykinin, histamine and phosphatidic acid

Prostaglandins, Leukotrienes, and Medicine
K Punnonen, T Puustinen

Abstract

The effects of bradykinin, histamine, phosphatidic acid and leukotrienes B4 and C4 on the distribution and release of 14C-arachidonic acid in human keratinocytes in culture were investigated. Bradykinin, histamine, and phosphatidic acid were found to liberate 14C-arachidonic acid from membrane phospholipids, whereas leukotrienes B4 and C4 were ineffective in this respect. The decrease in the labeling of phospholipids was accompanied by increased labeling of the non-phosphorus lipids. The present study suggests that bradykinin, histamine, and phosphatidic acid may interfere with the distribution and release of arachidonic acid in human keratinocytes in culture.

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Citations

Mentioned in this Paper

Histamine Measurement
KNG1
Arachidonic Acid
Keratinocyte
Phosphate Measurement
Bradykinin Assay
Phosphorus Measurement
Phosphatidic Acid
Arachidonic Acid Measurement
Phospholipids

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