journal cover

Interfering with the connection between the nucleus and the cytoskeleton affects nuclear rotation, mechanotransduction and myogenesis

The International Journal of Biochemistry & Cell Biology

Jul 14, 2010

Michaela BrosigRuth Chiquet-Ehrismann

Abstract

Mechanical stress controls a broad range of cellular functions. The cytoskeleton is physically connected to the extracellular matrix via integrin receptors, and to the nuclear lamina by the LINC complex that spans both nuclear membranes. We asked here how disruption of this direct link ...read more

Mentioned in this Paper

Myoblasts
Embryo
Real-Time Polymerase Chain Reaction
MYOG wt Allele
Biochemical Pathway
MYOD1 gene
Stress, Mechanical
Muscle Physiology
Transfection
Tissue Membrane
Paper Details
References
  • References54
  • Citations47
12345...
  • References54
  • Citations47
12345

Similar Papers Found In These Feeds

Phosphorylation

Phosphorylation is the attachment of a phosphoryl group, which is often provided by ATP, to a protein by a specific type of enzyme called kinase. Discover the latest research on phosphorylation here.

Signal Transduction & Control of Gene Expression

Expression of genes are thought to be involved in signaling pathways, which are important for cell growth, metabolism, apoptosis and more. It is thought that gene expression plays a part in the signaling pathways that implicates the biological effects of the cell. Here is the latest research on signal transduction and the control of gene expression.

Neuronal Guidance: Evolution

This feed focuses on mechanisms that underlie the evolution of axonal guidance pathways, neurogenesis, and synaptic connectivity. Here is the latest research.

Microtubules & Microtubule-Associated Proteins (Keystone)

Microtubule organization and dynamics are regulated by microtubule-associated proteins that interact with microtubules to regulate dynamic instability. Here is the latest research on microtubules and microtubule-associated proteins.

G-Protein-Coupled Receptors

G-protein-coupled receptors (GPCRs), the largest family of integral membrane proteins, participate in the regulation of many physiological functions and are the targets of approximately 30% of currently marketed drugs. Here is the latest research.

Signal Transduction & Gene Expression (Keystone)

Tumor cells have their own unique signal transduction and gene expression control. Targeting these specific cellular mechanisms and genetic proflies of cancer cells is an area of therapeutic exploration for some cancers. Discover the latest research on this topic with this feed.

Neurotoxicity, Inflammation & Neuroprotection

The end result of the inflammatory process, neurotoxicity and/or neuroprotection, is a function of the fine balance between the two cellular systems, i.e., of the complex signaling relationships between anti-inflammatory neuroprotective factors (neurotrophins and other chemical mediators) and proinflammatory neurotoxic factors (tnf, free radicals, certain cytokines, etc). Here are the latest discoveries pertaining to neurotoxicity, inflammation and neuroprotection.

Microtubules & Microtubule-Associated Proteins

Microtubule organization and dynamics are regulated by microtubule-associated proteins that interact with microtubules to regulate dynamic instability. Here is the latest research on microtubules and microtubule-associated proteins.

Nucleolar Dynamics

The nucleolus is the site of ribosome biogenesis, making ribosomal subunits from proteins and ribosomal RNA. Discover the latest research on nucleolar dynamics here.

Phosphoproteomics

Phosphoproteomics refers to the identification and quantification of phosphorylated proteins in the proteome. This approach provides a high-throughput method of examining the state of intracellular phosphorylation. Here is the latest research on phosphoproteomics.

Cytoskeletal Dynamics

The cytoskeleton is a dynamic system that is involved in numerous cellular functions. The dynamic cytoskeleton has a close relationship with formation and trafficking of vesicles, spindle localization, cell compartmentation and more. Here is the latest research on cytoskeletal dynamics.

Cytoskeletal Collection

The cytoskeleton is a dynamic network of interlinking protein filaments that extends from the plasma membrane to the nucleus. Here is the latest research.

Integrin Signalling

Integrins are transmembrane receptors that facilitate cell-extracellular matrix (ECM) adhesion. Upon ligand binding, integrins activate signal transduction pathways that mediate cellular signals such as regulation of the cell cycle, organization of the intracellular cytoskeleton, and movement of new receptors to the cell membrane. Discover the latest research on integrin signalling here.

Nuclear Transport

Nuclear transport refers to the import and export of large molecules into and out of the nucleus. This process is controlled by the nuclear pore complexes, where cargo bearing a nuclear localization or export signal is transported via nuclear transport receptors. Find the latest research on nuclear transport here.

Muscular Dystrophy

Muscular dystrophy refers to a range of muscle diseases caused by defects in muscle proteins, leading to death of the muscle cells, with loss of muscle tissue, and weakness. Here are the latest discoveries pertaining to this disease.

Cytoplasmic Biophysics

Cytoplasmic biophysics is an interdisciplinary science that applies approaches and methods traditionally used in physics to study the biological structure and function of cytoplasm which consists of cytosol and organelles. Discover the latest research on cytoplasmic biophysics here.

Signal Transduction & Gene Expression (Keystone)

Tumor cells have their own unique signal transduction and gene expression control. Targeting these specific cellular mechanisms and genetic proflies of cancer cells is an area of therapeutic exploration for some cancers. Discover the latest research on this topic with this feed.

PTMs of Transcription Factors (Keystone)

This feed focuses on post-translational modifications (PTMs) that occur on transcription factors, which may affect transcriptional processes.

Nuclear Envelope Dynamics

The nuclear envelope provides barrier between the nucleus and cytoplasm. It plays a key role in transport function and nuclear growth, organization, and integrity. Discover the latest research on nuclear envelope dynamics here.

Cytoskeleton & Cell Polarity

A dynamic cytoskeleton is critical for the generation of cell polarity. This feed focuses on cell polarity and the cytoskeleton, including actin and microtubular cytoskeletal organization.

Advanced Imaging of Cellular Signaling

Cell signaling is a vital mechanism for communication within cells and outside with the environment. Several different signaling pathways have been found and advanced imaging techniques are being developed to visualize the molecules involved in these signaling pathways. Find the latest research in advanced imaging of cellular signaling here.

Inflammatory Bowel Disease

Inflammatory bowel diseases (IBD), Crohn’s disease and ulcerative colitis, arise due to chronic inflammation of the gastrointestinal tract. Here is the latest research.

PTMs of Transcription Factors

This feed focuses on post-translational modifications (PTMs) that occur on transcription factors, which may affect transcriptional processes.

Mechanotransduction

Mechanotransduction refers to the processes through which cells sense and respond to mechanical stimuli by converting them to biochemical signals that elicit specific cellular responses. Discover the latest research on mechanotransduction here.

Adhesion Molecules in Health and Disease

Cell adhesion molecules are a subset of cell adhesion proteins located on the cell surface involved in binding with other cells or with the extracellular matrix in the process called cell adhesion. In essence, cell adhesion molecules help cells stick to each other and to their surroundings. Cell adhesion is a crucial component in maintaining tissue structure and function. Discover the latest research on adhesion molecule and their role in health and disease here.

Cytoskeleton & Cell Polarity

A dynamic cytoskeleton is critical for the generation of cell polarity. This feed focuses on cell polarity and the cytoskeleton, including actin and microtubular cytoskeletal organization.

Stress Fibers

Stress fibers are actin bundles found in non-muscle cells. Discover the latest research on stress fibers here.

Cytoskeletal & Motor Biophysics

Cytoskeletal motors of the dynein, kinesin and myosin superfamilies maintain and adapt subcellular organelle organization to meet functional demands and support the vesicular transport of material between organelles. Here is the latest research on cytoskeletal and motor biophysics.

MAPK Pathway

MAPK pathway is a complex signaling pathway that regulates transcription, translation, cell cycle, and proliferation. Targeting this pathway has long been considered a promising strategy for cancer therapy. Here is the latest research on this pathway.

Nuclear Export & Import of RNA

Nuclear import and export of RNA is a complex process involving several enzymes and receptors that recognize and bind to nuclear localization signals or nuclear export signals. Here is the latest research.

Lymphopenia

Lymphopenia has been associated with autoimmune pathology and it has been suggested that lymphopenia-induced proliferation of naive T cells may be responsible for the development of immune pathology. Here is the latest research.


Embryonic Neural Stem Cells

Embryonic neural stem cells can be used to investigate the effect of different toxins and molecules on the proliferation and differentiation of these cells. Discover the latest research of embryonic neural stem cells here.

© 2020 Meta ULC. All rights reserved

Interfering with the connection between the nucleus and the cytoskeleton affects nuclear rotation, mechanotransduction and myogenesis

The International Journal of Biochemistry & Cell Biology

Jul 14, 2010

Michaela BrosigRuth Chiquet-Ehrismann

PMID: 20621196

DOI: 10.1016/j.biocel.2010.07.001

Abstract

Mechanical stress controls a broad range of cellular functions. The cytoskeleton is physically connected to the extracellular matrix via integrin receptors, and to the nuclear lamina by the LINC complex that spans both nuclear membranes. We asked here how disruption of this direct link ...read more

Mentioned in this Paper

Myoblasts
Embryo
Real-Time Polymerase Chain Reaction
MYOG wt Allele
Biochemical Pathway
MYOD1 gene
Stress, Mechanical
Muscle Physiology
Transfection
Tissue Membrane

Similar Papers Found In These Feeds

Related Papers

Paper Details
References
  • References54
  • Citations47
12345...
  • References54
  • Citations47
12345
/papers/interfering-with-the-connection-between-the/20621196