Interferon-α -Mediated Activation of T Cells from Healthy and HIV-Infected Individuals Is Suppressed by Δ9 -Tetrahydrocannabinol

The Journal of Pharmacology and Experimental Therapeutics
Joseph E HenriquezNorbert E Kaminski

Abstract

Patients with HIV routinely use medicinal cannabinoids to treat neuropathic pain, anxiety, and human immunodeficiency virus (HIV)-associated wasting. However, Δ9-tetrahydrocannabinol (THC), the primary psychoactive cannabinoid in cannabis, suppresses T-cell function and secretion of interferons, both critically important in the antiviral immune response. Interferon-α (IFNα), a key cytokine in T-cell activation and peripheral control of HIV infection, can potentiate responsiveness to interleukin-7 (IL-7), a crucial homeostatic cytokine for peripheral T-cell maintenance. The objective of this investigation was to compare the response of T cells to stimulation by IFNα and IL-7 in T cells from healthy and HIV+ donors in the absence and presence of THC. To compare T-cell responses between healthy and HIV+ donors signaling through IFNα receptor, IFNα-induced expression of IL-7α receptor (IL-7Rα), cognate signaling through IL-7R, and on IL-7-mediated T-cell proliferation were measured by flow cytometry and real-time quantitative polymerase chain reaction. CD8+ T cells from HIV+ donors showed a diminished response to IFNα-induced phosphorylated signal transducer and activator of transcription-1 activation compared with CD8+ T cells fro...Continue Reading

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Citations

Mar 28, 2020·Journal of Neuroimmune Pharmacology : the Official Journal of the Society on NeuroImmune Pharmacology·Joseph E HenriquezNorbert E Kaminski
May 16, 2020·Journal of Neuroimmune Pharmacology : the Official Journal of the Society on NeuroImmune Pharmacology·Michael D RizzoNorbert E Kaminski
Aug 8, 2020·Journal of Neuroinflammation·Hannah A WangLinda Chang
Feb 16, 2021·Neuroscience Letters·Barkha J Yadav-Samudrala, Sylvia Fitting
Jul 3, 2021·Viruses·Sanjay B Maggirwar, Jag H Khalsa

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