Interferon-γ +874A/T polymorphism and hepatocellular carcinoma risk: a meta-analysis

Medical Science Monitor : International Medical Journal of Experimental and Clinical Research
Huan ZhouShi Zhou

Abstract

Studies have evaluated the association between interferon-γ (IFN-γ) +874A/T polymorphism and hepatocellular carcinoma (HCC) risk, but the results are controversial. We performed this meta-analysis to further investigate this association. Relevant studies were searched by using the PubMed, Web of Science, and Embase databases. Odds ratios (ORs) with 95% confidence intervals (CIs) were used to assess the strength of the association. Subgroup analysis and sensitivity analysis were conducted. Seven case-control studies (859 HCC patients and 1482 healthy controls) were identified to assess the association between IFN-γ +874A/T polymorphism and risk of HCC. IFN-γ +874A/T polymorphism was significantly associated with an increased risk of HCC (OR=1.38; 95% CI 1.12-1.70; P=0.002). In the subgroup analysis by ethnicity, IFN-γ +874A/T polymorphism was significantly associated with HCC risk in Asians (OR=1.42; 95% CI 1.08-1.87; P=0.01), but no significant association was found in Caucasians (OR=1.21; 95% CI 0.86-1.70; P=0.28). IFN-γ +874A/T polymorphism also increased HBV-induced HCC risk (OR=1.42; 95% CI 1.08-1.87; P=0.01). In the subgroup analysis by control source, IFN-γ +874A/T polymorphism was associated with HCC risk in hospital-bas...Continue Reading

References

Sep 1, 1990·Immunology Today·S Romagnani
Sep 2, 2006·Journal of Leukocyte Biology·Anuradha Budhu, Xin Wei Wang
Oct 9, 2013·Molecular and Cellular Biochemistry·Roli SaxenaJyotdeep Kaur

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Citations

Aug 4, 2016·Genetic Testing and Molecular Biomarkers·Ayse Feyda NursalSacide Pehlivan
Aug 28, 2016·Medical Science Monitor : International Medical Journal of Experimental and Clinical Research·Shuhong ZhangShuhong Zhang
Aug 30, 2016·World Journal of Gastroenterology : WJG·Mahmoud Fathy DondetiRoba Mohamed Talaat

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