Interferon-α (IFNα) neurotoxicity.

Cytokine & Growth Factor Reviews
Cari Fritz-French, William R Tyor

Abstract

Clinical studies indicate that increased central nervous system (CNS) interferon-alpha (IFNα) is associated with cognitive dysfunction in a wide variety of conditions. This has perhaps been best studied in HIV-associated neurocognitive disorders (HAND). These findings on IFNα neurotoxicity have been corroborated in animal studies. Probably the best demonstration of the neurotoxicity of IFNα was through the use of a mouse model of HAND, where it was shown that blocking IFNα with neutralizing antibodies prevented behavioral deficits and associated histopathological effects. In vitro studies have demonstrated a dose dependent, detrimental effect of IFNα on neuronal dendrites. Development of therapeutics that block IFNα may prove to be an effective treatment of HAND and other inflammatory conditions where there is increased CNS IFNα.

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Citations

Nov 22, 2013·Journal of Neuroimmune Pharmacology : the Official Journal of the Society on NeuroImmune Pharmacology·Edana CassolDana Gabuzda
Apr 4, 2013·Cytokine & Growth Factor Reviews·Markus J Hofer, Iain L Campbell
Mar 19, 2013·Viruses·Frédéric SorgeloosThomas Michiels
Feb 26, 2014·Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research·Cari Fritz-FrenchWilliam R Tyor
Apr 24, 2013·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Maria J PolyakChristopher Power
Nov 8, 2014·Parasite Immunology·Alexandru ParlogIldiko Rita Dunay
Dec 18, 2014·Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research·Cari F Kessing, William R Tyor
Feb 9, 2019·Current HIV/AIDS Reports·Rebecca T VeenhuisLucio Gama
May 16, 2020·Journal of Neuroimmune Pharmacology : the Official Journal of the Society on NeuroImmune Pharmacology·Michael D RizzoNorbert E Kaminski
Jul 12, 2020·Fluids and Barriers of the CNS·Amila OmeragicReina Bendayan
Apr 24, 2019·Translational Psychiatry·Akira YoshimiNorio Ozaki
Oct 8, 2021·Seminars in Neurology·Kathryn B HolroydHenrikas Vaitkevicius
Nov 16, 2021·Current HIV/AIDS Reports·Albert M AndersonJennifer Iudicello

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