Interferon-γ-producing immature myeloid cells confer protection against severe invasive group A Streptococcus infections.

Nature Communications
Takayuki MatsumuraKazuo Kobayashi

Abstract

Cytokine-activated neutrophils are known to be essential for protection against group A Streptococcus infections. However, during severe invasive group A Streptococcus infections that are accompanied by neutropenia, it remains unclear which factors are protective against such infections, and which cell population is the source of them. Here we show that mice infected with severe invasive group A Streptococcus isolates, but not with non-invasive group A Streptococcus isolates, exhibit high concentrations of plasma interferon-γ during the early stage of infection. Interferon-γ is necessary to protect mice, and is produced by a novel population of granulocyte-macrophage colony-stimulating factor-dependent immature myeloid cells with ring-shaped nuclei. These interferon-γ-producing immature myeloid cells express monocyte and granulocyte markers, and also produce nitric oxide. The adoptive transfer of interferon-γ-producing immature myeloid cells ameliorates infection in wild-type and interferon-γ-deficient mice. Our results indicate that interferon-γ-producing immature myeloid cells have a protective role during the early stage of severe invasive group A Streptococcus infections.

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Citations

Aug 21, 2013·Immunology and Cell Biology·Nicole L MessinaRicky W Johnstone
Apr 25, 2013·Nature Communications·Atsushi OtsukaKenji Kabashima
Sep 25, 2014·Immunogenetics·Deepak BhartiHimanshu Kumar
Oct 26, 2018·Proceedings of the National Academy of Sciences of the United States of America·Takashi ImaiSho Yamasaki
May 9, 2014·The Journal of Immunology : Official Journal of the American Association of Immunologists·Jane BryantXunrong Luo
Mar 26, 2013·The Journal of Immunology : Official Journal of the American Association of Immunologists·Yubin ZhangKatherine C MacNamara
Sep 22, 2012·European Journal of Immunology·Dhifaf SarhanAndreas Lundqvist
Aug 6, 2021·Nature Communications·Ina Annelies StelzerPetra Clara Arck

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Datasets Mentioned

BETA
GM-CSF

Methods Mentioned

BETA
FACS
flow cytometry
ELISA

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