Interferon-γ regulates discordant mechanisms of uveitis versus joint and axial disease in a murine model resembling spondylarthritis.

Arthritis and Rheumatism
J KezicH L Rosenzweig

Abstract

The spondylarthritides (such as ankylosing spondylitis) are multisystem inflammatory diseases that frequently result in uveitis. Despite the common co-occurrence of uveitis with arthritis, there has been no explanation for the susceptibility of the eye to inflammation. Using an innovative intravital videomicroscopic approach, we discovered the coexistence of uveitis with axial and peripheral joint inflammation in mice immunized with cartilage proteoglycan (PG). The aim of this study was to elucidate the characteristics of uveitis and test the impact of interferon-γ (IFNγ) deficiency on the eye versus the joint and spine. Female T cell receptor (TCR)-transgenic mice or IFNγ-knockout mice crossed to TCR-transgenic mice were immunized with PG. Uveitis was assessed by intravital videomicroscopy and histology. The clinical and histopathologic severity of arthritis and spondylitis were evaluated. The bone remodeling process within the spine was assessed by whole-body near-infrared imaging. Immunoblotting and immunofluorescence staining were used to examine the expression of PG and ADAMTS-5 and to examine the cellular composition of eyes with uveitis. PG neoepitopes along with the aggrecanase ADAMTS-5 were present in the eye, as they ...Continue Reading

References

Oct 1, 1990·International Ophthalmology·R B Nussenblatt
Aug 7, 1980·Nature·J T RosenbaumP R Egbert
Jan 14, 1998·Current Eye Research·M J VermaD Wakefield
Oct 31, 2003·Critical Reviews in Immunology·Tibor T GlantKatalin Mikecz
Nov 13, 2004·Annals of the Rheumatic Diseases·J ZouJ Sieper
Jan 11, 2005·Annals of the Rheumatic Diseases·T BárdosT T Glant
Aug 2, 2005·Arthritis and Rheumatism·Zoltán SzabóTibor T Glant
Jul 27, 2006·Arthritis and Rheumatism·Suzanne E BerloTibor T Glant
Nov 23, 2006·The Journal of Experimental Medicine·Jason DeVossMark S Anderson
Oct 2, 2007·Arthritis and Rheumatism·Lyndell L LimJames T Rosenbaum
Jan 8, 2008·The Journal of Immunology : Official Journal of the American Association of Immunologists·Yanxia CaoAlison Finnegan
Apr 4, 2008·Investigative Ophthalmology & Visual Science·Holly L RosenzweigJames T Rosenbaum
Jun 21, 2008·The Journal of Immunology : Official Journal of the American Association of Immunologists·Paul D DoodesAlison Finnegan
Dec 17, 2008·Investigative Ophthalmology & Visual Science·Holly L RosenzweigJames T Rosenbaum
Jan 3, 2009·Immunity·Yun Kyung LeeCasey T Weaver
Feb 4, 2009·The Journal of Clinical Investigation·David BendingAnne Cooke
Jun 26, 2009·Investigative Ophthalmology & Visual Science·Kate E KellerTed S Acott
Dec 24, 2009·The Journal of Immunology : Official Journal of the American Association of Immunologists·Paul D DoodesAlison Finnegan
Mar 3, 2010·Immunological Reviews·Gethin P Thomas, Matthew A Brown
Aug 4, 2010·Proceedings of the National Academy of Sciences of the United States of America·Kiran NistalaLucy R Wedderburn

❮ Previous
Next ❯

Citations

Apr 4, 2012·Nature Reviews. Rheumatology·James T Rosenbaum, Holly L Rosenzweig
Jan 25, 2012·Arthritis Research & Therapy·Jelena M KezicHolly L Rosenzweig
Jun 28, 2012·Current Rheumatology Reports·Daniel Wendling
Oct 18, 2016·Ocular Immunology and Inflammation·Julie GueudryBahram Bodaghi
May 24, 2018·Arthritis & Rheumatology·James T Rosenbaum, Andrew D Dick
Sep 27, 2014·Clinical & Experimental Ophthalmology·Ellen J LeeHolly L Rosenzweig
Oct 12, 2018·Nature Reviews. Rheumatology·James T Rosenbaum, Mark Asquith
Nov 28, 2014·The Journal of Immunology : Official Journal of the American Association of Immunologists·Jae DuganMichael P Davey
May 21, 2019·Current Opinion in Rheumatology·Sruthi Arepalli, James T Rosenbaum
Oct 28, 2020·Nature Communications·Ruth J NapierHolly L Rosenzweig

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cell Atlas of the Human Eye

Constructing a cell atlas of the human eye will require transcriptomic and histologic analysis over the lifespan. This understanding will aid in the study of development and disease. Find the latest research pertaining to the Cell Atlas of the Human Eye here.