Interferon-λ rs12979860 genotype and liver fibrosis in viral and non-viral chronic liver disease

Nature Communications
Mohammed EslamInternational Hepatitis C Genetics Consortium (IHCGC)

Abstract

Tissue fibrosis is a core pathologic process that contributes to mortality in ~45% of the population and is likely to be influenced by the host genetic architecture. Here we demonstrate, using liver disease as a model, that a single-nucleotide polymorphism (rs12979860) in the intronic region of interferon-λ4 (IFNL4) is a strong predictor of fibrosis in an aetiology-independent manner. In a cohort of 4,172 patients, including 3,129 with chronic hepatitis C (CHC), 555 with chronic hepatitis B (CHB) and 488 with non-alcoholic fatty liver disease (NAFLD), those with rs12979860CC have greater hepatic inflammation and fibrosis. In CHC, those with rs12979860CC also have greater stage-constant and stage-specific fibrosis progression rates (P<0.0001 for all). The impact of rs12979860 genotypes on fibrosis is maximal in young females, especially those with HCV genotype 3. These findings establish rs12979860 genotype as a strong aetiology-independent predictor of tissue inflammation and fibrosis.

References

Aug 1, 1996·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·P Bedossa, T Poynard
Jul 26, 2002·Briefings in Bioinformatics·Cathryn M Lewis
Jan 4, 2003·Gastroenterology·Marc G GhanyJay H Hoofnagle
Dec 25, 2003·Diabetes Care·UNKNOWN American Diabetes Association
May 26, 2005·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·David E KleinerUNKNOWN Nonalcoholic Steatohepatitis Clinical Research Network
Jan 28, 2006·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Keyur PatelJohn G McHutchison
May 25, 2006·Bioinformatics·Xavier SoléVíctor Moreno
Mar 3, 2007·The Journal of Clinical Investigation·John P Iredale
Dec 29, 2007·The Journal of Pathology·T A Wynn
Sep 15, 2009·Nature Genetics·Vijayaprakash SuppiahJacob George
Apr 21, 2010·Cell·Jon McClellan, Mary-Claire King
Mar 9, 2011·Liver International : Official Journal of the International Association for the Study of the Liver·Manuel Romero-GomezMarta Maraver
May 7, 2011·Nature Medicine·Wajahat Z MehalScott L Friedman
Jul 2, 2011·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Francesco MarabitaMassimo Colombo
Sep 21, 2011·PLoS Medicine·Vijayaprakash SuppiahUNKNOWN International Hepatitis C Genetics Consortium (IHCGC)
Dec 20, 2011·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Pierre-Yves BochudUNKNOWN ANRS HC EP 26 Genoscan Study Group
Mar 7, 2012·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Laura Gomez-SantosNaiara Beraza
Dec 27, 2012·JAMA : the Journal of the American Medical Association·Adriaan J van der MeerHarry L A Janssen
Mar 26, 2013·Liver International : Official Journal of the International Association for the Study of the Liver·Zoe RaglowYu-Jui Y Wan
May 25, 2013·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Mazen NoureddinMarc G Ghany
May 29, 2013·The Journal of Experimental Medicine·Stéphanie BibertUNKNOWN Swiss Hepatitis C Cohort Study
Aug 3, 2013·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Jason GrebelyUNKNOWN InC3 Study Group
Apr 29, 2014·Journal of Hepatology·Mohammed EslamGolo Ahlenstiel

❮ Previous
Next ❯

Citations

Nov 26, 2015·Journal of Hepatology·Mohammed EslamUNKNOWN International Liver Disease Genetics Consortium (ILDGC)
Dec 20, 2015·Viral Immunology·Sreedhar ChinnaswamyTapas K Kundu
Dec 20, 2015·Hepatology International·Mohammed Eslam, Jacob George
Jul 3, 2015·Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research·Olusegun O OnabajoLudmila Prokunina-Olsson
Sep 28, 2015·Metabolism: Clinical and Experimental·Paola Dongiovanni, Luca Valenti
Mar 18, 2016·The Journal of Infectious Diseases·Nasheed MoqueetUNKNOWN Canadian Co-infection Cohort
Jul 23, 2015·Immunity·Helen M LazearMichael S Diamond
Jan 30, 2016·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Mohammed EslamUNKNOWN International Liver Disease Genetics Consortium
Dec 31, 2015·Liver International : Official Journal of the International Association for the Study of the Liver·Stéphane BuhlerUNKNOWN Swiss Hepatitis C Cohort Study (SCCS) and Swiss Transplant Cohort Study (STCS)
Oct 28, 2016·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Marianne MartinelloGail V Matthews
Jan 22, 2017·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Khaled ThabetMohammed Eslam
May 4, 2017·PloS One·Nasheed MoqueetUNKNOWN Canadian Co-infection Cohort Study (CTN 222)
May 18, 2017·Nature Communications·Scott A ReadGolo Ahlenstiel
Mar 7, 2017·Liver International : Official Journal of the International Association for the Study of the Liver·Emeline GauthiezUNKNOWN Swiss Hepatitis C Cohort Study
May 26, 2017·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Mark H KuniholmThomas R O'Brien
Jul 14, 2017·PloS One·Rosario López-RodríguezPaloma Sanz-Cameno
Jul 21, 2017·Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research·Anand BhushanSreedhar Chinnaswamy
Nov 21, 2017·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Heiyoung ParkBarbara Rehermann
Dec 16, 2017·Virus Genes·Fabiana CannellaAlessandra Pierangeli
Oct 27, 2017·The Journal of Immunology : Official Journal of the American Association of Immunologists·Adeola A ObajemuOlusegun O Onabajo
Jun 24, 2017·The Journal of Immunology : Official Journal of the American Association of Immunologists·Yanshi WangZhigang Tian
Jul 3, 2018·Alimentary Pharmacology & Therapeutics·R El SharkawyM Eslam
Jul 22, 2015·Nature Immunology·Andreas WackRune Hartmann
Sep 16, 2016·Nature Communications·Khaled ThabetUNKNOWN International Liver Disease Genetics Consortium
Jan 10, 2019·Hepatology Research : the Official Journal of the Japan Society of Hepatology·Emi Inoue-ShinomiyaMamoru Watanabe
Mar 1, 2019·Viral Immunology·Mohammad IrshadKhushboo Irshad
Apr 19, 2019·Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research·Thomas R O'BrienLudmila Prokunina-Olsson
Apr 24, 2019·Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research·Mohammed EslamJacob George
Jun 5, 2019·Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research·Thomas R O'Brien, Sarah S Jackson
Dec 18, 2015·World Journal of Gastroenterology : WJG·Yuki HagaOsamu Yokosuka
Sep 4, 2019·ELife·Thomas R O'BrienLudmila Prokunina-Olsson
Jul 18, 2019·Digestive Diseases and Sciences·Naga Swetha SamjiSanjaya K Satapathy
May 18, 2016·Journal of Acquired Immune Deficiency Syndromes : JAIDS·Mark H KuniholmKathryn Anastos
Feb 27, 2020·Human Genetics·Pierre Nahon, Aurélie Cobat

❮ Previous
Next ❯

Methods Mentioned

BETA
biopsy
biopsies
genotyping

Software Mentioned

StepOne
SPSS
SAS

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.