PMID: 6162102Jan 29, 1981Paper

Interferon action--sequence specificity of the ppp(A2'p)nA-dependent ribonuclease

Nature
D H WreschnerI M Kerr

Abstract

The oligonucleotides pppA2'p5'A2'p5'A and related oligomers (2-5A) are synthesized by an enzyme that is widely distributed in a variety of cells, the activity of which varies with interferon treatment, growth and hormone status. Because significant amounts of 2-5A have recently been detected in interferon-treated cells, it has been suggested that the oligonucleotides may be involved in interferon action and in the control of cell metabolism. In both intact cells and cell-free systems 2-5A has been shown to activate a ribonuclease. We report here investigations of the sequence specificities of the 2-5A-dependent ribonucleases in extracts of rabbit reticulocytes, mouse ascites tumour cells and human lymphoblastoid cells in conditions of partial digestion using terminally labelled RNA substrates. The enzymes cleaved on the 3'-side of UN sequences to yield UpNp terminated products. Cleavage was observed predominantly at UA and UU sequences.

References

Jul 1, 1979·Proceedings of the National Academy of Sciences of the United States of America·A G HovanessianL Montagnier
Sep 1, 1979·FEBS Letters·B R WilliamsI M Kerr
Jan 1, 1978·Proceedings of the National Academy of Sciences of the United States of America·I M Kerr, R E Brown
Oct 1, 1979·Proceedings of the National Academy of Sciences of the United States of America·E SlatteryP Lengyel
Apr 1, 1979·Proceedings of the National Academy of Sciences of the United States of America·D A Peattie
Aug 1, 1977·Nucleic Acids Research·H Donis-KellerW Gilbert
Apr 1, 1978·Nucleic Acids Research·J J Skehel, A J Hay
May 30, 1978·Biochemistry·T E England, O C Uhlenbeck
Jan 1, 1980·Annals of the New York Academy of Sciences·M RevelR Bendori
Feb 1, 1980·Virology·A G Hovanessian, J N Wood
Jun 11, 1980·Nucleic Acids Research·J F ObijeskiJ J Skehel

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Citations

Jul 17, 2001·Journal of Cellular Biochemistry. Supplement·H SaitoH Ishii
Jan 1, 1992·The International Journal of Biochemistry·H C SchröderW E Müller
Jan 1, 1989·Toxicon : Official Journal of the International Society on Toxinology·S SalzbergY Nitzan
Jan 1, 1984·Pharmacology & Therapeutics·G C Sen
Dec 1, 1994·Journal of Virological Methods·B A Hassel, P O Ts'o
Oct 18, 1983·Biochimica Et Biophysica Acta·T J BorelliJ M Wu
May 7, 2004·Veterinary Immunology and Immunopathology·A K NichaniP J Griebel
Jun 1, 2005·Experimental and Molecular Pathology·Marc FrémontPatrick Englebienne
Jun 12, 1998·Pharmacology & Therapeutics·M R Player, P F Torrence
Jul 27, 2007·Nature·Krishnamurthy MalathiRobert H Silverman
Dec 1, 2007·Nature Reviews. Drug Discovery·Ernest C BordenGeorge R Stark
Jun 26, 2008·Nature Reviews. Immunology·Anthony J Sadler, Bryan R G Williams
Sep 1, 1987·Proceedings of the National Academy of Sciences of the United States of America·R ReevesK R Johnson
Feb 15, 1993·Proceedings of the National Academy of Sciences of the United States of America·P F TorrenceR H Silverman
Jun 25, 1996·Proceedings of the National Academy of Sciences of the United States of America·A MitraR H Silverman
Dec 4, 2003·Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research·Rie TatsumiYoshihiro Sokawa
Oct 1, 1987·Journal of Interferon Research·P Lengyel
Oct 22, 1998·Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research·S T ShorsB L Jacobs
Jun 13, 2008·Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research·Peter Lengyel
Dec 31, 2010·Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research·Arindam ChakrabartiRobert H Silverman
Jan 22, 1982·Nucleic Acids Research·B K Saha
Jan 20, 2011·Nucleic Acids Research·Jesper Buchhave PoulsenPia Møller Martensen
Apr 15, 1983·European Journal of Biochemistry·M C HaughI M Kerr

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