Interferon activation in primary Sjögren's syndrome: recent insights and future perspective as novel treatment target

Expert Review of Clinical Immunology
Iris L A Bodewes, Marjan A Versnel

Abstract

Primary Sjögren's syndrome (pSS) is one of the most common systemic autoimmune diseases. At the moment, there is no cure for this disease and its etiopathology is complex. Interferons (IFNs) play an important role in the pathogenesis of this disease and are a potential treatment target. Areas covered: Here we discuss the role of IFNs in pSS pathogenesis, complications encountered upon studying IFN-induced gene expression, and comment on the current knowledge on easy clinical applicable 'IFN signatures'. The current treatment options targeting IFNs in pSS are summarized and the perspective of potential new strategies discussed. Expert commentary: The authors provide their perspective on the role of IFNs in pSS and how this knowledge could be used to improve pSS diagnosis, provide new treatment targets, to monitor clinical trials and to stratify pSS patients in order to move toward precision medicine.

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Citations

May 29, 2019·Current Opinion in Rheumatology·Elena BartoloniRoberto Gerli
Nov 2, 2018·International Journal of Molecular Sciences·Muhammad Shahnawaz SoyfooChristine Delporte
Jun 6, 2019·Clinical Reviews in Allergy & Immunology·Amandine CharrasYves Renaudineau
May 22, 2019·Frontiers in Immunology·Elena BartoloniRoberto Gerli
Jan 23, 2021·Expert Review of Clinical Immunology·Loukas ChatzisAndreas V Goules
Jan 22, 2021·Autoimmunity Reviews·Muhammad S Soyfoo, Charles Nicaise
Jun 8, 2021·Expert Review of Clinical Immunology·Vassilis E PapadopoulosClio P Mavragani
Aug 3, 2021·Frontiers in Immunology·Juliana Imgenberg-KreuzGunnel Nordmark
Nov 4, 2021·BioDrugs : Clinical Immunotherapeutics, Biopharmaceuticals and Gene Therapy·Bin WangGuixiu Shi

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