PMID: 8583134Nov 1, 1995Paper

Interferon alfa-2b for chronic hepatitis C: effects of dose increment and duration of treatment on response rates. Results of the first multicentre Australian trial. Australia Hepatitis C Study Group

Journal of Hepatology
R LinG C Farrell

Abstract

Two hundred and thirty patients with histologically proven chronic hepatitis C were randomized to receive one of the following treatment protocols: (a) 3 million units of interferon alfa-2b thrice weekly for 6 months, (b) 5 million units thrice weekly for 6 months, or (c) 3 million units thrice weekly for 2 years. The short-term response to treatment was defined by normal alanine aminotransferase for at least 3 months and until the end of treatment, and was confirmed by loss of hepatitis C viraemia in 42 (91%) of 46 cases as determined by reverse transcription-polymerase chain reaction. Short-term response to interferon alfa-2b was independent of the incremental dose, being 64% for 5 million units and 58% for 3 million units. Long-term response to interferon alfa-2b was defined by continued normality of alanine aminotransferase levels for at least 6 months after treatment withdrawal. The long-term response rates among responders treated for 6 months and those treated for 2 years were 29% and 54%, respectively (p < 0.001). Among all 18 patients tested, serum HCV-RNA was negative at both 6 and 12 months of follow-up in all long-term responders, and none have subsequently relapsed. Improvement in hepatic necroinflammatory changes ...Continue Reading

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Citations

Dec 18, 2001·Journal of Medical Virology·E SagnelliF Piccinino
Dec 1, 1996·Digestive Diseases and Sciences·G C Farrell
Dec 1, 1996·Digestive Diseases and Sciences·T PoynardJ P Zarski
Dec 1, 1996·Digestive Diseases and Sciences·P FerenciA Gangl
Jun 1, 2005·Bioorganic & Medicinal Chemistry·Kazue SasakiShoji Nishiyama
Mar 20, 2004·Journal of Hepatology·Johannes T BrouwerUNKNOWN Benelux Study Group On Treatment Of Chronic Hepatitis C
Jun 28, 2005·The Journal of Infection·Atsushi HokariGotaro Toda
Jan 6, 2000·Journal of Hepatology·A CraxïM Giunta
Jan 6, 2000·Journal of Hepatology·G L Davis
Dec 22, 1999·Journal of Viral Hepatitis·S KakizakiM Mori
Jun 10, 2000·Journal of Viral Hepatitis·L A KondiliA Mele
Oct 24, 2002·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Dinesh KumarJacob George
Jan 30, 1997·The New England Journal of Medicine·J H Hoofnagle, A M di Bisceglie
Oct 1, 1996·Journal of Clinical Gastroenterology·H NomuraS Kashiwagi
Jan 1, 1997·Journal of Viral Hepatitis·W G Cooksley
Jan 1, 1997·Journal of Viral Hepatitis·W G CooksleyK Watson
Oct 14, 2009·Journal of Gastroenterology and Hepatology·Geoff McCaughan
Jun 27, 2000·Australian and New Zealand Journal of Medicine·U DuttaG C Farrell
Jan 1, 2010·Pharmacogenomics and Personalized Medicine·Roberto J Carvalho-Filho, Olav Dalgard
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