Abstract
To report a possible association between interferon alfa therapy and anterior ischemic optic neuropathy (AION). Database study and review of the literature. Thirty-six case reports from spontaneous reporting systems and the literature. Case reports from a review of the literature were combined with spontaneous reports from the National Registry of Drug-Induced Ocular Side Effects, the World Health Organization, and the Food and Drug Administration looking for reports on interferon therapy associated with optic neuropathy. Data from the spontaneous reports include the type of interferon, age, gender, adverse drug reaction (ADR), dosage, duration of therapy until onset of ADR, concomitant drugs, systemic disease, and dechallenge and rechallenge data. Thirty-six case reports of AION are described in association with interferon alfa therapy. The average age of subjects was 54.5 years; 26 were male and 10 were female. The median duration of therapy to onset of AION was 4.5 months, with 50% of subjects having some form of permanent vision loss. Anterior ischemic optic neuropathy was bilateral in 67% of subjects. There are 3 positive rechallenge case reports. Interferon alfa's association with AION can be classified as "possible" usin...Continue Reading
References
May 2, 1980·Science·D Brouty-Boyé, B R Zetter
Aug 1, 1995·Archives of Ophthalmology·V A Purvin
Sep 1, 1994·Journal of Hepatology·E K ManesisS Hadziyannis
Feb 1, 1994·Drug Safety : an International Journal of Medical Toxicology and Drug Experience·I R Edwards, C Biriell
May 15, 1994·American Journal of Ophthalmology·S S HayrehW L Alward
Mar 1, 1993·Archives of Ophthalmology·D R GuyerJ W Miller
May 29, 1998·The British Journal of Ophthalmology·S HayasakaS Sato
Apr 28, 1999·Lancet·C P LohmannJ Preuner
Oct 12, 1999·Ophthalmologica. Journal international d'ophtalmologie. International journal of ophthalmology. Zeitschrift für Augenheilkunde·F NorciaC Redaelli
May 30, 2002·The American Journal of Medicine·Rajiv GuptaJade S Schiffman
Sep 5, 2002·Cancer·John M KirkwoodRuth Mascari
Oct 26, 2002·Journal of Hepatology·Gabriel PerlemuterPatrice Cacoub
May 9, 2003·European Neurology·M SinnreichR Sztajzel
Jul 11, 2003·Ocular Immunology and Inflammation·Toshihiko Matsuo, Ryu Takabatake
Dec 10, 2003·Journal of Neuro-ophthalmology : the Official Journal of the North American Neuro-Ophthalmology Society·Yoav VardizerAnat Kesler
Jun 23, 2004·Journal of Neuro-ophthalmology : the Official Journal of the North American Neuro-Ophthalmology Society·Rod Foroozan
Oct 2, 2004·Klinische Monatsblätter für Augenheilkunde·A KirchhoffR Guthoff
Jun 26, 2007·World Journal of Gastroenterology : WJG·Damien SenePatrice Cacoub
Mar 6, 2008·European Journal of Ophthalmology·M FodorG Pfliegler
Mar 28, 2008·Journal of Viral Hepatitis·J McHutchison, M Sulkowski
Oct 2, 2008·Internal Medicine·Hirohisa OkumaShigeharu Takagi
Feb 6, 2009·American Journal of Clinical Oncology·Alan J RodneyNizar M Tannir
Feb 10, 2009·Gastroentérologie Clinique Et Biologique·N KabbajN Amrani
Apr 23, 2009·Deutsche medizinische Wochenschrift·A Chrissafidou, E Musch
Nov 26, 2009·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Julian Schulze Zur Wiesch, Ansgar W Lohse
Citations
Nov 16, 2012·Clinical Ophthalmology·Kelly S RueAlfredo A Sadun
Dec 24, 2013·World Journal of Gastroenterology : WJG·Roderick O'DayGolo Ahlenstiel
Apr 3, 2014·Hepatitis Monthly·Ligita JancorieneEvelina Balciunaite
May 16, 2012·Ophthalmology·Alejandro Saint-JeanNicolas Molina-Prat
Mar 21, 2015·Journal of Neuro-ophthalmology : the Official Journal of the North American Neuro-Ophthalmology Society·Dean M CestariDimosthenis Mantopoulos
Oct 29, 2015·Journal français d'ophtalmologie·A Rousseau, M Labetoulle
Oct 27, 2017·Clinical and Molecular Hepatology·Lisa Humbertjean-SeltonSébastien Richard
Apr 6, 2019·Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research·Natalia LewczukJoanna Bogusławska
Mar 4, 2020·Cancers·Charlotte LiisborgTorben Lykke Sørensen
Dec 14, 2018·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·Zubir S RentiyaMostafa Hanout
Apr 4, 2021·Viruses·Chia-Min WuChih-Ching Yeh
May 29, 2021·Survey of Ophthalmology·Supriya AroraJay Chhablani