PMID: 8590891Jan 1, 1995Paper

Interferon alpha-2a and external beam radiotherapy in the initial management of patients with glioma: a pilot study of the National Biotherapy Study Group

Cancer Biotherapy
R O DillmanC DePriest

Abstract

The National Biotherapy Study Group conducted a phase I/II trial of alpha-interferon (IFN) plus radiation therapy (RT) in glioma patients to confirm the feasibility of combining these two modalities. Patients newly diagnosed gliomasreceived external beam RT as 180 cGy in 33 fractions over six to seven weeks, five days a week, and IFN at a dose of 3 MIU SC Monday, Wednesday and Friday of each week. IFN was increased to 5 MIU after two weeks and was given for up to 16 weeks. Patients were monitored for toxicity and failure-free and overall survival. There were 12 men and seven women with an age range of 24-77, and a median age of 64 years. There were 12 glioblastomas and seven advanced astrocytomas. Complete surgical resection was carried out in two patients, nine had a partial resection, and eight had a biopsy only. Two patients in the latter group deteriorated rapidly and received < 2 weeks of RT/IFN. One patient stopped IFN because of a skin rash, another stopped because of concurrent pneumonia, and one patient was noncompliant. RT and IFN were well-tolerated; 14 of the 19 patients completed the eight weeks of IFN/RT. However, only three patients took IFN for the maximum of 16 weeks. The only grade 4 toxicities noted were incr...Continue Reading

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Citations

Jun 10, 2011·Neurosurgical Review·Kenichiro IwamiToshihiko Wakabayashi
Feb 11, 1998·International Journal of Radiation Oncology, Biology, Physics·S V RajkumarR P Dinapoli
Jun 22, 2001·Critical Reviews in Oncology/hematology·R L HayesC Zaroulis
Jul 10, 2014·Journal of Cancer Research and Clinical Oncology·Wei ZhouZhenyu Shao
Oct 18, 2002·Cephalalgia : an International Journal of Headache·O Sjaastad, T A Fredriksen
Oct 20, 2020·Cancer Chemotherapy and Pharmacology·Xiang-Rong NiZhong-Ping Chen

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