Interferon-alpha-associated sarcoidosis responsive to infliximab therapy

The American Journal of the Medical Sciences
Yamini MenonLuis R Espinoza

Abstract

Sarcoidosis, a multisystem disease characterized by noncaseating granulomas, has been reported to be associated with interferon alpha (IFN-alpha) therapy for hepatitis C infection. INF-alpha is known to stimulate T helper cells with a Th1 profile immune response, which is the key immunologic event of a sarcoid granuloma formation. We report a patient treated with IFN-alpha who developed hypercalcemia and renal insufficiency as presenting clinical manifestation of sarcoidosis. Prednisone therapy was effective in controlling hypercalcemia but had to be discontinued due to an increase in hepatitis C viral RNA count. Infliximab, a chimeric monoclonal antibody directed against tumor necrosis factor alpha was used as therapy in our patient for its known potent anti-inflammatory effects. The patient received three doses of infliximab (5 mg/kg) and achieved a rapid decline in serum calcium to normal levels in 7 days; the serum calcium level has remained normal 3 months after the last infusion.

References

Apr 7, 1983·The New England Journal of Medicine·P PinkstonR G Crystal
Feb 1, 1997·American Journal of Respiratory Cell and Molecular Biology·I BäumerJ Müller-Quernheim
Jul 22, 1998·Journal of Hepatology·R M HoffmannG R Pape
Jul 17, 1999·International Journal of Immunopharmacology·N MagyF Stoll-Keller
Jan 13, 2000·Chest·N J Vander Els, H Gerdes
Jun 22, 2001·AJR. American Journal of Roentgenology·J G RavenelT A Sporn
Feb 5, 2002·Journal of Gastroenterology·Shilun D LiDavid H Van Thiel
Apr 10, 2002·Archives of Dermatology·Jeanne WendlingBéatrice Crickx
Aug 7, 2002·Journal of Gastroenterology·Shinwa YamadaYoshiya Tanaka
Apr 4, 2003·Lancet·Robert P BaughmanRoland M du Bois
Jun 26, 2003·JAMA : the Journal of the American Medical Association·Karl W Thomas, Gary W Hunninghake
Nov 11, 2003·Scandinavian Journal of Infectious Diseases·Sauro Luchi, Antonio Scasso
Dec 16, 2003·Arthritis and Rheumatism·Kai U UlbrichtReinhold E Schmidt
Jan 14, 2004·Archivos de bronconeumología·I Alfageme MichavilaJ López Garrido

❮ Previous
Next ❯

Citations

Aug 6, 2011·Nature Reviews. Gastroenterology & Hepatology·Majid A AlmadiSubrata Ghosh
Sep 2, 2005·Respirology : Official Journal of the Asian Pacific Society of Respirology·Göhkan CelikSelim Karayalcin
Feb 3, 2006·International Journal of Clinical Practice·S Alazemi, M A Campos
Nov 15, 2008·World Journal of Gastroenterology : WJG·Ned SnyderShu-Yuan Xiao
Feb 18, 2011·Current Rheumatology Reports·Nadera J SweissRobert P Baughman
Jun 10, 2011·Expert Opinion on Biological Therapy·Raj PatelJennifer A Cafardi
Oct 23, 2008·The American Journal of the Medical Sciences·Jean-Jacques MonsuezBrigitte Autran
Oct 2, 2012·Dermatologic Clinics·Joshua W HagenA Neil Crowson
Mar 6, 2012·Seminars in Arthritis and Rheumatism·Jose Ramon ManeiroUNKNOWN BIOBADASER Study Group
Jun 1, 2010·La Revue de médecine interne·E Toussirot, E Pertuiset
Oct 25, 2006·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Adam R BerlinerMichael J Choi
Jan 26, 2007·Advances in Dermatology·Leonid Izikson, Joseph C English
Jul 27, 2006·Allergy·W J Pichler
Dec 28, 2006·Journal of the American Academy of Dermatology·Julia E GravesMichael P Heffernan
Feb 21, 2006·Journal of the American Academy of Dermatology·Brian J Nickoloff, Seth R Stevens
Aug 10, 2006·Néphrologie & thérapeutique·Svetlana KarieGilbert Deray
May 6, 2006·Respiratory Medicine·Hilary J GoldbergJay Peters
Oct 7, 2006·Journal of Clinical Rheumatology : Practical Reports on Rheumatic & Musculoskeletal Diseases·Mittie K DoyleJeanette H Magnus
Oct 16, 2008·The American Journal of Gastroenterology·Ellen C EbertKlaus D Hagspiel
Jul 23, 2008·Ophthalmic Plastic and Reconstructive Surgery·Catherine J Hwang, Roberta E Gausas
Jun 16, 2005·Current Opinion in Rheumatology·Manuel Ramos-Casals, Josep Font
Sep 23, 2009·Melanoma Research·Carlos Suárez-GarcíaFrancisco Miguel Camacho
Mar 11, 2010·European Journal of Gastroenterology & Hepatology·Pierre FauriePascal Sève
Jan 31, 2007·Clinical Science·Bart G DenysAn S De Vriese
Feb 2, 2008·Endocrine Practice : Official Journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists·Adriana G IoachimescuAngelo Licata
Apr 27, 2018·Chest·Amit ChopraMarc A Judson
Jun 30, 2021·Current Opinion in Pulmonary Medicine·Jelle Miedema, Hilario Nunes

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.