PMID: 9527339Apr 4, 1998Paper

Interferon alpha for ocular Behçet's disease

Acta Ophthalmologica Scandinavica
P Pivetti-PezziG Valesini

Abstract

To investigate the therapeutic role of interferon alpha in ocular Behçet's disease. Three patients with B- or C-hepatitis and ocular sight-threatening Behçet's disease unresponsive to steroids were treated subcutaneously with interferon alpha 3 x 10(6)/unit three times per week for a mean period of 22 months (range: 12-31 months). The course of ocular and systemic lesions was recorded and compared with a similar pre-treatment period. At least a 50% reduction in the number of ocular relapses was observed in all the patients (mean relapse/month: 0.41 versus 0.16 in the pre- and in-treatment period, respectively) while during therapy also each relapse lasted less in all subjects. A reduction of steroid dependence was observed in all patients, while no significant side-effects were related to interferon alpha administration. Two patients who tried to stop interferon alpha therapy showed after a mean period of 12.5 days a recurrence of diffuse uveitis and, one of them experienced oral and genital aphthae as well. In patients with Behçet's disease interferon alpha seems to be a useful alternative therapy for sight-threatening ocular involvement.

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Citations

Jun 13, 2006·Clinical & Experimental Ophthalmology·Lyndell LimJustine R Smith
Dec 3, 2014·Clinical and Experimental Medicine·Gianluigi MazzoccoliAngelo De Cata
Nov 12, 2005·Seminars in Ophthalmology·Adriana A Bonfioli, Fernando Orefice
Jun 23, 2012·Rheumatology·Daniela PerraGerard Espinosa
Mar 23, 2001·Ocular Immunology and Inflammation·B WechslerP LeHoang
Feb 24, 2007·International Ophthalmology·Valerie TouitouBahram Bodaghi
Jul 2, 2009·Paediatric Drugs·Srilakshmi M SharmaAthimalaipet V Ramanan
Feb 13, 2002·Arthritis and Rheumatism·Justine R Smith, James T Rosenbaum
Oct 26, 2018·Journal of Ocular Pharmacology and Therapeutics : the Official Journal of the Association for Ocular Pharmacology and Therapeutics·Hande CelikerHaner Direskeneli
Jun 8, 2007·Japanese Journal of Ophthalmology·Massimo AccorintiPaola Pivetti-Pezzi
Aug 31, 2000·Clinical Immunology : the Official Journal of the Clinical Immunology Society·S Hegab, S Al-Mutawa
Jul 27, 2010·Seminars in Arthritis and Rheumatism·Esperanza PatoUNKNOWN Uveitis Working Group from Spanish Society of Rheumatology
Jun 3, 2021·Journal of Clinical Medicine·Julie GueudryBahram Bodaghi
Aug 2, 2008·American Journal of Ophthalmology·Muge R KesenHoward H Tessler

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