Interferon-alpha for prophylaxis of recurrent viral hepatitis C in liver transplant recipients: a prospective, randomized, controlled trial

Transplantation
N SinghI R Marino

Abstract

In a randomized, controlled trial, we sought to determine whether prophylaxis with interferon-alpha for 6 months had an impact on rate, severity, and timing of onset of recurrent hepatitis C virus (HCV) hepatitis in liver transplant recipients and to assess whether interferon use was associated with rejection in liver transplant recipients. Twenty-four consecutive liver transplant recipients with HCV were randomized after transplantation to receive either interferon-alpha (3 million U three times weekly) for 6 months or no prophylaxis; median follow-up was 874 days. Recurrent HCV hepatitis (histopathologically proven) developed in 50% (6 of 12) of the interferon-alpha patients versus 42% (5 of 12) of the control patients (P=NS). Severity of recurrence (as assessed by Knodell score on liver biopsies) also did not differ between the two groups (mean 4.0 for interferon-alpha patients versus 3.5 for control patients, P=NS). Interferon-alpha, however, significantly delayed the timing of occurrence of HCV hepatitis; recurrent HCV hepatitis developed a median of 408 days after transplant in the interferon-alpha group versus 193 days in the control group (P=0.05). No difference in graft or patient survival was demonstrated in the two g...Continue Reading

References

Oct 1, 1992·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·L D FerrellJ Lake
Feb 15, 1991·Annals of Internal Medicine·A E ReadT L Wright
Dec 1, 1987·Annals of Internal Medicine·J D MeyersK M Sullivan
Sep 1, 1981·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·R G KnodellJ Wollman
Oct 1, 1994·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·T L WrightM Urdea
Apr 1, 1994·Gastroenterology·O ChazouilleresM Urdea
Mar 28, 1996·The New England Journal of Medicine·E J GaneR Williams
Nov 1, 1996·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·S ZhouT L Wright

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Citations

Jul 18, 2000·Journal of Medical Virology·R TeixeiraA K Burroughs
Aug 2, 2000·Journal of Gastroenterology and Hepatology·E Gane
Sep 12, 2000·Current Gastroenterology Reports·T BizollonC Trepo
Mar 1, 2002·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Montserrat Garcia-RetortilloJuan Rodes
Oct 4, 2002·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·Ed Gane
Oct 31, 2003·Current Treatment Options in Gastroenterology·Michelle M. Lipman, Scott J. Cotler
Oct 31, 2003·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·Marius Braun, John M Vierling
Oct 19, 2004·European Journal of Gastroenterology & Hepatology·Lorna M Dove
Jul 28, 2006·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·E OtonM L Mateos
Sep 26, 2006·Annals of Surgery·Andrew M CameronRonald W Busuttil
Jan 30, 2009·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·Fredric D GordonHugo E Vargas
Nov 11, 2009·Medical Microbiology and Immunology·Jan Peveling-OberhagWolf Peter Hofmann
Aug 18, 2012·International Journal of Hepatology·Nobuhisa Akamatsu, Yasuhiko Sugawara
May 28, 2013·Clinical & Developmental Immunology·Shih-Hsien HsuShen-Nien Wang
Nov 2, 2001·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·H R Rosen
Sep 28, 2000·The American Journal of Gastroenterology·G SzaboH L Bonkovsky
Feb 3, 2005·Transplant International : Official Journal of the European Society for Organ Transplantation·Bruno Roche, Didier Samuel
Nov 9, 2002·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·Roberto J FirpiDavid R Nelson
Jun 27, 2007·Alimentary Pharmacology & Therapeutics·R R ArjalH R Rosen
Feb 14, 2006·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·A Kuo, N A Terrault
Nov 8, 2005·World Journal of Gastroenterology : WJG·Yun Ma, Wen-Wei Yan
Dec 15, 2010·Hepatitis Research and Treatment·Yasuhiko SugawaraNorihiro Kokudo
Mar 31, 2009·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Marc G GhanyUNKNOWN American Association for the Study of Liver Diseases
Mar 16, 2007·Liver International : Official Journal of the International Association for the Study of the Liver·Rosângela TeixeiraThomas D Schiano
Nov 30, 2000·Current Infectious Disease Reports·M P Epstein, T Knox
Oct 27, 2001·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·J AhmadA O Shakil
Oct 4, 2002·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·Didier Samuel
Feb 24, 2004·Drugs·Susan E ChanHugo R Rosen
Feb 9, 2005·Transplantation·Christos TriantosAndrew Burroughs
Sep 25, 2004·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·Ryan A McTaggartSandy Feng
Mar 27, 2002·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Jennifer E Layden, Thomas J Layden
Oct 7, 2006·Current Opinion in Gastroenterology·K A Brown, D K Moonka
Jul 19, 2003·Journal of Clinical Gastroenterology·Sammy Saab, Victor Wang
Oct 31, 2003·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·Norah A Terrault
Jul 9, 2002·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·A KornbergJ Scheele
Oct 3, 2006·Journal of Hepato-biliary-pancreatic Surgery·Shigeru MarubashiMorito Monden
Jan 16, 2009·Transplant Infectious Disease : an Official Journal of the Transplantation Society·S DingesUNKNOWN Swiss Association for the Study of the Liver (SASL 17)
Nov 21, 2000·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·A K Burroughs
May 31, 2001·Journal of Viral Hepatitis·R TeixeiraA K Burroughs
Jan 19, 2002·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·Giorgio BallardiniFrancesco Bianco Bianchi
Apr 2, 2004·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Doris B StraderUNKNOWN American Association for the Study of Liver Diseases
May 7, 2010·Current Opinion in Organ Transplantation·Ayse AytamanNorah A Terrault
Apr 9, 2008·Journal of Hepato-biliary-pancreatic Surgery·Sumihito Tamura, Yasuhiko Sugawara

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