Interferon alpha-induced apoptosis on rat preneoplastic liver is mediated by hepatocytic transforming growth factor beta(1)

Hepatology : Official Journal of the American Association for the Study of Liver Diseases
María de Luján AlvarezMaría Cristina Carrillo

Abstract

In previous work we showed that interferon alfa-2b (IFN-alpha2b) increases apoptosis on rat hepatic preneoplastic foci. The aim of this study was to determine if transforming growth factor beta1 (TGF-beta1) was involved in the programmed cell death on the foci. Animals were divided into 6 groups: subjected to a 2-phase model (diethylnitrosamine plus 2-acetylaminofluorene) of preneoplasia development (group 1); treated with IFN-alpha2b during the 2 phases (group 2); treated with IFN-alpha2b during initiation with diethylnitrosamine (group 3); treated with IFN-alpha2b during 2-acetylaminofluorene administration (group 4); subjected only to an initiation stage (group 5); and treated with IFN-alpha2b during the initiation period (group 6). Serum TGF-beta1 levels were increased in IFN-alpha2b-treated rats. Immunohistochemical studies showed that IFN-alpha2b significantly increased the quantity of TGF-beta1-positive hepatocytes in groups 2 to 4. Phosphorylated-Smads-2/3 (p-Smads-2/3) proteins in liver nuclear extracts were significantly elevated. To determine the source of TGF-beta1, isolated hepatocytes, Kupffer cells, and peritoneal macrophages from animals in groups 1 and 5 were cultured with or without IFN-alpha2b. IFN-alpha2b st...Continue Reading

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Citations

Mar 7, 2007·Archives of Toxicology·Juan Pablo ParodyMaría Cristina Carrillo
Dec 27, 2005·Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research·Katja PokrovskajaDan Grandér
Jun 28, 2006·Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research·Corneliu SandaMilton W Taylor
Jun 21, 2014·Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research·María Paula CeballosMaría Cristina Carrillo
Nov 13, 2008·Growth Factors·María De Luján AlvarezMaría Cristina Carrillo
Aug 22, 2006·Expert Opinion on Biological Therapy·Stanislas Pol, Vincent O Mallet
Oct 15, 2013·Molecular Nutrition & Food Research·María Laura CasellaMaría de Luján Alvarez
Dec 3, 2013·Liver International : Official Journal of the International Association for the Study of the Liver·Juan P ParodyMaria C Carrillo
Mar 21, 2007·Biochemical Pharmacology·Ariel D QuirogaMaría Cristina Carrillo
Feb 13, 2014·Physiological Genomics·Brad RybinskiEdna Cukierman
Jun 14, 2020·International Journal of Clinical Practice·Bruna C BertolEduardo A Donadi
Jun 21, 2021·The Journal of Nutritional Biochemistry·Marina C VeraAriel D Quiroga

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