PMID: 8938572Nov 1, 1996Paper

Interferon-alpha inhibits CFU-GM mobilization following chemotherapy and G-CSF administration

Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research
P BallarinoI Pannacciulli

Abstract

Changes in routine hematologic data and in circulating granulocyte-macrophage colony-forming units (CFU-GM) during granulocyte colony-stimulating factor (G-CSF) administration were evaluated in non-small cell lung carcinoma (NSCLC) patients treated with a combination of 5-fluorouracil (5-FU) and cisplatin (DDP) with and without the addition of interferon-alpha (IFN-alpha). The patterns of leukocyte changes following chemotherapy plus G-CSF were similar in both the IFN-alpha-inclusive and the IFN-alpha-devoid courses. However, the twofold increase in CFU-GM observed in patients receiving chemotherapy plus G-CSF was completely absent following the course including IFN-alpha. The activity of G-CSF on the hematologic pattern is seemingly affected by its combination with IFN-alpha treatment. Mechanisms of the possible in vivo interaction among IFNs and hematopoietic growth factors remain to be elucidated.

References

Dec 1, 1989·Proceedings of the National Academy of Sciences of the United States of America·B I LordT M Dexter
May 1, 1985·The Journal of Clinical Investigation·S W MamusE D Zanjani
Nov 11, 1993·Nature·T Hunter

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Citations

Aug 4, 1998·European Journal of Haematology·I PannacciulliG Bogliolo

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