PMID: 8603932Nov 1, 1995Paper

Interferon-alpha preserves erythrocyte and hepatocyte ATPase activities from liver damage induced by prolonged bile duct ligation in the rat

Journal of Applied Toxicology : JAT
P Muriel

Abstract

Interferons have been used to treat chronic hepatitis owing to their antiviral properties. However, now interferons are recognized to inhibit collagen production. Because fibrosis has been associated with liver damage and dysfunction, the effects of interferon-alpha 2b on biliary obstruction-induced cirrhosis were investigated. Obstructive jaundice was induced in male Wistar rats (ca. 200 g) by double ligation and division of the common bile duct. Control rats were sham operated. Interferon-alpha 2b (IFN-alpha; 1000 000 IU per rat) was administered subcutaneously daily after surgery. The animals were sacrificed after 4 weeks of bile duct ligation (BDL) or sham operation. Bilirubins and serum enzyme activities of alkaline phosphatase and gamma-glutamyl transpeptidase (determined as markers of liver damage) increased several-fold after BDL. Erythrocyte and hepatocyte plasma membrane Na+/K+- and Ca2+-ATPase activities decreased significantly in the BDL group. Administration of IFN-alpha to BDL rats resulted in a partial normalization of serum markers of liver damage. The normal activity of both ATPases on erythrocyte and hepatocyte plasma membranes was completely preserved by IFN-alpha. It is concluded that interferons possess int...Continue Reading

References

Aug 4, 1976·Biochimica Et Biophysica Acta·A DietmaierM Peterlik
Dec 15, 1978·Biochimica Et Biophysica Acta·G G GuidottiG C Gazzola
Nov 1, 1989·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·M J CzajaM A Zern
Apr 1, 1987·The Journal of Clinical Investigation·R D GransteinE P Amento
Jul 1, 1985·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·G DusheikoM Kew
Apr 1, 1969·The Journal of Physiology·H J Schatzmann, F F Vincenzi
Jul 1, 1970·Proceedings of the National Academy of Sciences of the United States of America·P B Dunham, J F Hoffman
Aug 13, 1971·Biochimica Et Biophysica Acta·M Chau-Wong, P Seeman
Jan 12, 1983·Biochimica Et Biophysica Acta·K S Lee, K S Au
Jan 1, 1980·Physiological Reviews·D A Hems, P D Whitton
Jan 1, 1983·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·R Pérez Tamayo
Jan 1, 1982·The Journal of Membrane Biology·M S Kilberg
Jan 15, 1982·Biochemical Pharmacology·T Iga, C D Klaassen
Nov 1, 1994·Journal of Applied Toxicology : JAT·P Muriel, O R Suarez
Sep 1, 1993·British Journal of Clinical Pharmacology·B C IsraelS I Shedlofsky
Jan 1, 1972·FEBS Letters·H Glossmann, D M. Neville

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Citations

Apr 30, 2011·BMC Gastroenterology·Orhan TarcinNurdan Tözün
Oct 30, 2007·Journal of Applied Toxicology : JAT·Pablo Muriel, Yadira Rivera-Espinoza

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