Abstract
Rickettsia prowazekii Madrid E established persistent infections in cultures of growing L-929 cells. Although some L-929 cells died, the cultures survived, remained infected with rickettsiae, and continued to grow. R. prowazekii Madrid E also induced interferon in L-929 cell cultures, and this interferon modulated rickettsial growth. Production of interferon (anti-viral activity) by cultures of R. prowazekii-infected L-929 cells was directly related to the initial rickettsial infection and was blocked by erythromycin. The media collected from R. prowazekii-infected L-929 cells suppressed not only the replication of vesicular stomatitis virus but also the growth of R. prowazekii in fresh L-929 cells. Both anti-viral and anti-rickettsial activities in the media were neutralized by antibodies against murine interferons-alpha and -beta, but not by antibodies against murine interferon-gamma. In addition, a commercial preparation of virus-induced interferons-alpha and -beta also suppressed rickettsial growth in L-929 cells. The combination of treating L-929 cells with this virus-induced interferon and infecting them with R. prowazekii killed some of the L-929 cells.
References
May 1, 1979·Journal of Clinical Microbiology·T S Walker, H H Winkler
Jun 1, 1976·Infection and Immunity·C L WissemanD J Silverman
Jun 1, 1975·Infection and Immunity·C L Wisseman, A D Waddell
Jun 1, 1989·Infection and Immunity·J Turco, H H Winkler
Oct 1, 1989·Journal of Interferon Research·J TurcoH H Winkler
Jan 1, 1985·Critical Reviews in Microbiology·J W Foster, D M Kinney
May 1, 1987·Infection and Immunity·H LiD H Walker
Dec 1, 1972·Antimicrobial Agents and Chemotherapy·E A Havell, J Vilcek
Mar 1, 1983·The Journal of Experimental Medicine·J Turco, H H Winkler
Oct 1, 1983·Infection and Immunity·J Turco, H H Winkler
Dec 1, 1983·The Journal of Experimental Medicine·J Turco, H H Winkler
Aug 1, 1984·Infection and Immunity·J Turco, H H Winkler
Aug 1, 1980·Infection and Immunity·D J SilvermanA Waddell
Dec 1, 1982·Canadian Journal of Microbiology·W J ToddA J Mavros
Apr 1, 1950·Journal of Bacteriology·M R BOVARNICKJ C SNYDER
Jun 1, 1971·Infection and Immunity·J KazarF B Gordon
Citations
Sep 26, 2013·Future Microbiology·Sanjeev K SahniDavid H Walker
Sep 21, 2018·Frontiers in Immunology·Chan-Ki MinNam-Hyuk Cho
May 1, 1991·Infection and Immunity·J Turco, H H Winkler
Oct 1, 1993·Infection and Immunity·J Turco, H H Winkler
Nov 1, 1991·Infection and Immunity·B Hanson
Nov 1, 1991·Infection and Immunity·B Hanson
Jun 1, 1994·Infection and Immunity·J Turco, H H Winkler
Aug 1, 1994·Infection and Immunity·J Turco, H H Winkler
Jun 1, 1993·Infection and Immunity·Q GaoH H Winkler
Oct 1, 1990·Infection and Immunity·J Turco, H H Winkler
Aug 24, 2021·ELife·Thomas P BurkeMatthew D Welch