PMID: 2116101Jan 1, 1990Paper

Interferon-alpha/beta and Rickettsia prowazekii: induction and sensitivity

Annals of the New York Academy of Sciences
J Turco, H H Winkler

Abstract

Rickettsia prowazekii Madrid E established persistent infections in cultures of growing L-929 cells. Although some L-929 cells died, the cultures survived, remained infected with rickettsiae, and continued to grow. R. prowazekii Madrid E also induced interferon in L-929 cell cultures, and this interferon modulated rickettsial growth. Production of interferon (anti-viral activity) by cultures of R. prowazekii-infected L-929 cells was directly related to the initial rickettsial infection and was blocked by erythromycin. The media collected from R. prowazekii-infected L-929 cells suppressed not only the replication of vesicular stomatitis virus but also the growth of R. prowazekii in fresh L-929 cells. Both anti-viral and anti-rickettsial activities in the media were neutralized by antibodies against murine interferons-alpha and -beta, but not by antibodies against murine interferon-gamma. In addition, a commercial preparation of virus-induced interferons-alpha and -beta also suppressed rickettsial growth in L-929 cells. The combination of treating L-929 cells with this virus-induced interferon and infecting them with R. prowazekii killed some of the L-929 cells.

References

May 1, 1979·Journal of Clinical Microbiology·T S Walker, H H Winkler
Jun 1, 1989·Infection and Immunity·J Turco, H H Winkler
Jan 1, 1985·Critical Reviews in Microbiology·J W Foster, D M Kinney
Dec 1, 1972·Antimicrobial Agents and Chemotherapy·E A Havell, J Vilcek
Mar 1, 1983·The Journal of Experimental Medicine·J Turco, H H Winkler
Dec 1, 1983·The Journal of Experimental Medicine·J Turco, H H Winkler
Dec 1, 1982·Canadian Journal of Microbiology·W J ToddA J Mavros

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Citations

Sep 26, 2013·Future Microbiology·Sanjeev K SahniDavid H Walker

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