PMID: 6165339Jan 1, 1981Paper

Interferon and adrenocorticotropic hormone induction of steroidogenesis, melanogenesis and antiviral activity

Archives of Virology
J E Blalock, C Harp

Abstract

Adrenocorticotropic hormone (ACTH) and mouse but not human interferon caused a steroidogenic response and induced antiviral activity in mouse adrenal tumor (Y-1) cells. ACTH and human but not mouse interferon caused induction of melanin synthesis and antiviral activity in human melanoma cells. ACTH did not induce antiviral activity in mouse L or human amnion (WISH) cells. The hormonal activities of interferon were neutralized by specific rabbit anti-interferon sera. Thus, interferon has species-specific hormonal activity and ACTH has cell-specific antiviral activity. These results are discussed in terms of the possible natural functions of interferon polypeptide hormones.

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Citations

Jan 1, 1991·Biotherapy·C Grunfeld, K R Feingold
Sep 1, 1989·Journal of Affective Disorders·M MaesJ Raus
Jan 1, 1989·Psychoneuroendocrinology·D Saphier
Jan 1, 1995·European Psychiatry : the Journal of the Association of European Psychiatrists·S Cervera-Enguix, A Rodríguez-Rosado
Dec 30, 1988·Biochemical and Biophysical Research Communications·W C GorospeB G Kasson
Dec 1, 1981·Proceedings of the National Academy of Sciences of the United States of America·E M Smith, J E Blalock
Jul 1, 1982·Proceedings of the National Academy of Sciences of the United States of America·H M JohnsonJ E Blalock
Jan 1, 1986·Journal of Toxicology and Environmental Health·R J SmialowiczR W Luebke
Jan 1, 1990·Journal of Pineal Research·B WithyachumnarnkulR J Reiter
Jan 1, 1990·Annals of the New York Academy of Sciences·D A WeigentJ E Blalock
Jan 1, 1989·The Journal of Clinical Investigation·K KameyamaV J Hearing
Oct 1, 1986·Journal of Neuroimmunology·J RoosthW J Meyer
Apr 1, 1990·The International Journal of Neuroscience·A CataniaC Zanussi
Nov 1, 1985·Clinics in Endocrinology and Metabolism·J E BlalockW J Meyer
Dec 1, 1987·Immunological Reviews·D A Weigent, J E Blalock
Jan 1, 1991·Neuroscience and Biobehavioral Reviews·C R Plata-Salamán
Sep 3, 2014·PloS One·Venkatraman SiddharthanJohn D Morrey
Aug 1, 1990·Journal of Interferon Research·B WithyachumnarnkulR J Reiter
Jun 1, 1989·International Reviews of Immunology·D J Carr, J E Blalock
Feb 1, 1994·Journal of Endocrinological Investigation·J FukataK Nakao
Jan 1, 1983·Archives of Virology·A D Inglot

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