PMID: 41163Jan 1, 1979

Interferon and cytotoxic factor (cytotoxin) released in the blood of mice infected with Mycobacterium bovis BCG. I. Enhanced production of interferon and appearance of cytotoxin stimulated by capsular polysaccharide of Klebsiella pneumoniae or bacterial lipopolysaccharide

Microbiology and Immunology
N KatoT Kojima


Interferon production stimulated by the active substance (neutral fraction) of the capsular polysaccharide of Klebsiella pneumoniae (neutral CPS-K) in BCG-infected mice was compared with that by bacterial lipopolysaccharide (LPS). Prior infection with BCG increased the responsiveness of mice to the lethal effect of neutral CPS-K as well as to that of LPS. Associated with this, BCG-infected mice showed a markedly enhanced ability to produce interferon after stimulation not only by LPS but also by neutral CPS-K. In addition, a cytotoxic factor (cytotoxin) was found to be released in the serum of BCG-infected mice after injection of these inducers. The kinetics of production of interferon and cytotoxin stimulated by neutral CPS-K were very similar to those stimulated by LPS. The time pattern of cytotoxin production was not in parallel with that of interferon production. Interferon reached a peak 2 hr and cytotoxin 3 hr after injection with these inducers. Interferon and cytotoxin produced by neutral CPS-K showed essentially the same stabilities to heating at 56 C and to treatment at pH 2 respectively as those produced by LPS. Interferon was inactivated by heating at 56 C more rapidly than cytotoxin. Cytotoxin was inactivated by tr...Continue Reading


Sep 1, 1975·Proceedings of the National Academy of Sciences of the United States of America·E A CarswellB Williamson
Jun 1, 1974·The Journal of Experimental Medicine·G B MACKANESST Ishibashi
Jul 1, 1973·The Journal of Infectious Diseases·S M Wolff
May 1, 1969·The Journal of Experimental Medicine·R V BlandenG B MACKANESS
Dec 1, 1968·Proceedings of the National Academy of Sciences of the United States of America·W P Kolb, G A Granger
May 1, 1970·Cellular Immunology·W P Kolb, G A Granger
Oct 1, 1958·Proceedings of the Society for Experimental Biology and Medicine·E SUTERR G HOFFMAN
Jul 1, 1964·The Journal of Experimental Medicine·G B MACKANESS
May 1, 1965·The Journal of Experimental Medicine·K SAITO, E SUTER
May 1, 1965·The Journal of Experimental Medicine·K SAITO, E SUTER

Related Concepts

Salmonella enteritidis
Polysaccharides, Bacterial
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Lethal Dose 50
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