Interferon and interferon-induced chemokine expression is associated with control of acute viremia in West Nile virus-infected blood donors.

The Journal of Infectious Diseases
Leslie H ToblerMichael P Busch

Abstract

To understand early host responses controlling West Nile virus (WNV) infection, acutely viremic blood donors, identified by nucleic acid amplification testing, were enrolled and monitored for RNA-clearance and WNV-specific IgM and IgG antibodies. Viral load and chemokine and cytokine assays were performed on serial samples from donors whose index and first follow-up samples tested negative for IgM. A total of 84% of the specimens obtained from viremic donors before IgM/IgG seroconversion demonstrated a decreasing viral load. Levels of interferon (IFN)-alpha were significantly increased before IgM seroconversion, relative to those in control specimens. CXCL10 and CCL2 were significantly elevated in donor specimens obtained before IgM seroconversion, compared with those obtained after IgM seroconversion. These findings suggest that IFN-mediated innate immunity plays a key role in initial control of WNV replication.

References

Sep 10, 2004·The Journal of Immunology : Official Journal of the American Association of Immunologists·William G GlassPhilip M Murphy
Dec 8, 2004·Nature Medicine·Michael S Diamond, Robyn S Klein
Aug 5, 2005·The New England Journal of Medicine·Michael P BuschSteven H Kleinman
Aug 5, 2005·The New England Journal of Medicine·Lyle R Petersen, Jay S Epstein
Aug 17, 2005·Journal of Virology·Robyn S KleinMichael S Diamond
May 10, 2006·Cellular Microbiology·Akinori Takaoka, Hideyuki Yanai
Sep 26, 2006·Vaccine·Michael M LiebermanCarolyn Weeks-Levy
Apr 21, 2007·Epidemiology and Infection·R M VorouS Tsiodras
May 17, 2007·Journal of Neurovirology·David Garcia-TapiaSteven B Kleiboeker

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Citations

May 2, 2012·Immunologic Research·Susana V Bardina, Jean K Lim
May 17, 2011·AIDS·Sheila M KeatingUNKNOWN Women's Interagency HIV Study
Oct 5, 2012·Clinical Microbiology Reviews·Tonya M ColpittsErol Fikrig
Jun 24, 2011·Clinical and Vaccine Immunology : CVI·Elizabeth Crabb BreenPhilip J Norris
Oct 27, 2009·The Journal of Clinical Investigation·Marion C LanteriPhilip J Norris
Aug 23, 2011·PLoS Neglected Tropical Diseases·Alyson A KelvinSalvatore Rubino
Oct 10, 2009·PLoS Pathogens·Fengwei BaiErol Fikrig
Jun 3, 2010·The Open Virology Journal·Marina MoniniFranco Maria Ruggeri
Mar 13, 2014·Viral Immunology·Feng QianRuth R Montgomery
Jun 30, 2012·Cytokine & Growth Factor Reviews·Sheila M KeatingPhilip J Norris
Oct 24, 2014·PLoS Neglected Tropical Diseases·José PeñaPejman Naraghi-Arani
Aug 30, 2008·The Journal of Infectious Diseases·Michael P BuschSally Caglioti
Apr 29, 2011·Médecine sciences : M/S·Marion C LanteriMichael P Busch
Apr 24, 2020·PLoS Neglected Tropical Diseases·Marion CléYannick Simonin
Nov 20, 2018·Frontiers in Cellular and Infection Microbiology·Magali GarciaCharles Bodet
May 27, 2020·Journal of Immunology Research·Patricio L AcostaLaura B Talarico
Feb 1, 2015·Expert Review of Anti-infective Therapy·Ruth R Montgomery, Kristy O Murray
Oct 31, 2019·BMC Infectious Diseases·Bixing HuangDavid Warrilow
Apr 21, 2021·Journal of Neurovirology·Sambor GrygorczukAnna Moniuszko-Malinowska

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Methods Mentioned

BETA
nucleic acid-amplification
ELISA

Software Mentioned

SPSS

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