Interferon and meta-iodobenzylguanidin combinations in the treatment of metastatic carcinoid tumours

Endocrine-related Cancer
J M ZuetenhorstB G Taal

Abstract

Interferon (IFN) and meta-iodobenzylguanidin (MIBG) are active in metastatic carcinoids. In a phase II study, we evaluated the effect upon diagnostic 131I-MIBG uptake and the clinical response of the combination. 131I-MIBG scintigraphy was performed prior to treatment, after 8 weeks of IFN and after unlabelled MIBG. The tumour over non-tumour (T/NT) ratios were quantitatively determined by comparing counts in the centre of the tumour (liver metastases) with those in an adjacent area of normal liver uptake (T/NT1) and with abdominal background area (T/NT2). The T/NT1 ratio showed an increase of >10% in only four out of 21 patients (19%) after IFN (P = 0.178) and significantly more often in nine out of 18 patients (50%) after unlabelled MIBG (P = 0.016). The absolute uptake in tumour deposits was also increased if compared with the abdominal background (T/NT2: 23% increase after IFN and 83% increase after unlabelled MIBG). The combination produced 91% of patients with stable disease (using World Health Organisation criteria) at computed tomography scan and a biochemical response (a reduction of at least 50% in urinary 5-hydroxyindolacetic acid excretion) in 39%. IFN-alpha did not significantly improve tumour retention of 131I-MIB...Continue Reading

Citations

Feb 11, 2005·Current Gastroenterology Reports·Babs G Taal
Feb 2, 2010·Seminars in Nuclear Medicine·Frank Grünwald, Samer Ezziddin
Dec 11, 2007·European Journal of Surgical Oncology : the Journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology·J BendelowG J Poston
Sep 27, 2005·Best Practice & Research. Clinical Gastroenterology·Tahir Shah, Martyn Caplin
Aug 8, 2015·Cancer Metastasis Reviews·P Jiménez-FonsecaUNKNOWN Spanish Neuroendocrine Tumor Group (GETNE)
Apr 2, 2013·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Jan Maarten van der ZwanUNKNOWN RARECARE WG
Feb 15, 2005·The Oncologist·Johanna M Zuetenhorst, Babs G Taal

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