PMID: 6166575Oct 15, 1980Paper

Interferon and spontaneous cytotoxicity in man. V. Enhancement of spontaneous cytotoxicity in patients receiving human leukocyte interferon

International Journal of Cancer. Journal International Du Cancer
S EinhornH Strander

Abstract

The effect of daily injections of 3 x 10(6) units of human leukocyte IF on the spontaneous cytotoxicity of peripheral lymphocytes was studied in 43 patients with a variety of diseases. An increase in spontaneous cytotoxicity was observed 12 to 24 h after the first IF injection with the peak of activity occurring, in most cases, at 24 h. In some patients a decrease in spontaneous cytotoxicity, observed 6 h after the injection, preceded this increase. The increment in spontaneous cytotoxicity was not significantly correlated to preinjection level of cytotoxicity, disease, age, sex, previous therapy, leukocyte counts or proportions of lymphocytes and monocytes. A second injection of IF maintained the spontaneous cytotoxicity at an increased level and during prolonged IF therapy, up to 9 months, the cytotoxicity remained elevated. IF treatment in vitro caused an enhancement of spontaneous cytotoxicity in lymphocytes drawn prior to IF injection. This IF-induced increase in cytotoxicity in vitro was correlated to the increase in cytotoxicity induced by IF in vivo. Six hours after the first IF injection the ability of IF in vitro to enhance spontaneous cytotoxicity was decreased and during prolonged therapy the ability of IF in vitro ...Continue Reading

References

Feb 3, 1979·Lancet·H MellstedtH Strander
Jan 1, 1979·Acta Medica Scandinavica·K IdeströmJ Willems
Oct 1, 1979·The Journal of Infectious Diseases·S IngimarssonH Strander
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Citations

Jan 1, 1983·Cancer Metastasis Reviews·M Introna, A Mantovani
Jan 1, 1986·Toxicon : Official Journal of the International Society on Toxinology·J W BurnettL Aurelian
Jan 1, 1984·Critical Reviews in Oncology/hematology·R V Smalley, R K Oldham
Jan 1, 1982·Journal of Interferon Research·C H ScorticattiR Comolli
Jun 1, 1985·The Journal of Clinical Investigation·B S EdwardsE C Borden
Oct 1, 1983·European Journal of Cancer & Clinical Oncology·S RotsteinB Johansson
Aug 9, 2007·Cytokine & Growth Factor Reviews·Hans Strander
Nov 1, 1985·Clinical Immunology and Immunopathology·R L Hirsch, K P Johnson
May 1, 1986·Clinical Immunology and Immunopathology·M Abbud-FilhoT B Strom
Jan 1, 1991·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·W R BezwodaJ Keeping
Jul 1, 1984·Clinical Immunology and Immunopathology·A P KellyM S Hirsch
Sep 1, 1987·Biological Psychiatry·R KrishnanJ Ritchie
Mar 1, 1993·Journal of Hepatology·C N d'ArvilleR Williams
Jan 1, 1985·Journal of Immunopharmacology·L J CharamellaN V Dimitrov
Sep 24, 1982·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·H Strander, S Einhorn
Feb 15, 1984·International Journal of Cancer. Journal International Du Cancer·S EinhornU Ohman
Mar 1, 1984·Infection and Immunity·S Einhorn, C Jarstrand

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